Inhomogeneous dose distribution in a serial organ architecture
L. Spiazzi, P. Feroldi
Medical Physics Department, Spedali Civili Hospital, Brescia (Italy)
Manuscript received: March 14, 2000; revised: August 21, 2000
Accepted for publication: August 23, 2000.
Abstract
Some statistical assumptions and biophysical simplifications are essential in order to develop models to be used in clinical routine radiotherapy to compute Normal Tissue Complication Probability (NTCP). We focused on the assumption of binomial statistical description of cell radiation killing. We designed a basic tissue and organ architecture by means of serial combinations of functional subunits (FSU). NTCP calculations for our modelling procedure are shown. It is shown that when a fixed mean dose is delivered to the serially structured tissue the homogeneous dose distribution minimises NTCP.
KEYWORDS: NTCP, DVH, organ modelling.