VOL. XVII, Supplement 1, 2001
Proceedings of the "1 st International Workshop on Space Radiation Research and 11 th Annual NASA Space Radiation Health Investigators’ Workshop", Arona (Italy), May 27-31, 2000
Foreword
W. Schimmerling
Preface
R. Cirio, F.A. Cucinotta, M. Durante
Index
General lectures
J. Kiefer
Space radiation research in the new millenium – from where
we come and where we go.
F.A. Cucinotta
Once we know all the radiobiology we need to know, how can we use
it to predict space radiation risks, and achieve fame and
fortune?
G. Kraft
What we can learn from heavy ion therapy for radioprotection in
space.
E.J. Hall
Genomic Instability, Bystander Effect, Cytoplasmic Irradiation
and other phenomena that may achieve fame without fortune.
Space Radiation and Hadrontherapy: a synergistic interaction
D.I. Lowenstein
BNL Accelerator-Based Radiobiology Facilities.
G.A. Nelson, L.M. Green, D.S.
Gridley, J.O. Archambeau, J.M. Slater
Research Activities at the Loma Linda University and Proton
Treatment Facility - An overview.
U. Amaldi
The Italian hadrontherapy project CNAO
H. Nikjoo, S. Uehara, I.G.
Khvostunov, F.A. Cucinotta, D.T. Goodhead
Monte Carlo track structure for radiation biology and space
applications.
J. Miller
Recent measurements for hadrontherapy and space radiation:
nuclear physics.
E.A. Blakely
New Measurements for Hadrontherapy and Space Radiation: Biology.
NSCORT session
A. Chatterjee, T.H. Borak
Physical and biological studies with protons and HZE particles in
a NASA supported research center in radiation health.
Computer codes and calculations
J. Wilson, F.A. Cucinotta, M.Y.
Kim, W. Schimmerling
Optimized Shielding for Space Radiation Protection.
A. Ferrari, J. Ranft, P.R. Sala
The FLUKA radiation transport code and its use for space
problems.
M.H.Y. Kim, S.A. Thibeault, J.W.
Wilson, L. Heilbronn, R.L. Kiefer, J.A. Weakley, J.L. Dueber, T.
Fogarty, R. Wilkins
Radiation Protection Using Martian Surface Materials in Human
Exploration of Mars.
Contents
L.W. Townsend
Overview of active methods for shielding spacecraft from
energetic space radiation.
L.S. Pinsky, T.L. Wilson, A.
Ferrari, P. Sala, F. Carminati, R. Brun
Development of a space radiation Monte-Carlo computer simulation
based on the FLUKA and ROOT codes.
R.C. Singleterry Jr, J.W. Wilson,
J.L. Shinn, R.K. Tripathi, S.A. Thibeault, A.K. Noor, F.A.
Cucinotta, F.F. Badavi, C.K. Chang, G.D. Qualls, M.S. Clowdsley,
M.-H.Y. Kim, J.H. Heinbockel, J. Norbury, S.R. Blattning, J.
Miller, C. Zeitlin, L.H. Heilbronn
Creation and Utilization of a World Wide Web Based Space
Radiation Effects Code: SIREST.
M.S. Clowdsley, J.W. Wilson,
M.-H.Y. Kim, R.C. Singleterry, R.K. Tripathi, J.H. Heinbockel,
F.F. Badavi, J.L. Shinn
Neutron Environments on the Martian Surface.
U. Schneider, A. Lomax, N.
Lombriser
Comparative Treatment Planning using Secondary Cancer Mortality
Calculations.
L. Cella, A. Lomax, R. Miralbell
New Techniques in Hadrontherapy: Intensity Modulated Proton
Beams.
M. Biaggi, F. Ballarini, A.
Ferrari, A. Ottolenghi, M. Pelliccioni
A Monte-Carlo code for a direct estimation of radiation risk.
P.B. Saganti, E.N. Zapp, J.W.
Wilson, F.A. Cucinotta
Visual Assessment of the Radiation Distribution in the ISS Lab
Module: Visualization in the Human Body.
D. Emfietzoglou, G. Papamichael,
M. Moscovitch
Monte-Carlo simulation of charged particle transport in
biomatter.
Physical measurements
A. Ferrari, A. Mitaroff, M.
Silari
A reference radiation facility for dosimetry at flight altitude
and in space.
W. Hajdas, A. Zehnder, L. Adams,
P. Buehler, R. Harboe-Sorensen, M. Daum, R. Nickson, E. Daly, P.
Nieminen
Proton Irradiation Facility and Space Radiation Monitoring at the
Paul Scherrer Institute.
A. Moroni, U. Abbondanno, C.
Agodi, R. Alba, F. Ballarini, G. Bellia, M. Biaggi, M. Bruno, G.
Casini, S. Cavallaro, R. Cherubini, M. Chiari, M. Colonna, R.
Coniglione, M. D’Agostino, A. Del Zoppo, A. Giussani, F.
Gramegna, C. Maiolino, G.V. Margagliotti, P.F. Mastinu, E.
Migneco, P.M. Milazzo, A. Nannini, A. Ordine, A. Ottolenghi, P.
Piattelli, D. Santonocito, P. Sapienza, G. Vannini, L. Vannucci,
E. Vardaci
Nuclear detecting systems at LNL and LNS: foreseen experiments to
provide basic data for heavy-ion risk assessment.
T. Berger, M. Hajek, W. Schöner,
M. Fugger, N. Vana, M. Noll, R. Ebner, Y. Akatov, V. Shurshakov,
V. Arkhangelsky
Measurement of the Depth Distribution of Average LET and Absorbed
Dose Inside a Water-Filled Phantom on Board Space Station MIR.
M.R. Shavers, F.A. Cucinotta, J.
Miller, C. Zeitlin, L. Heilbronn, J.W. Wilson, R.C. Singleterry
Jr.
Shielded Heavy-Ion Environment Linear Detector (SHIELD): An
Experiment for the Radiation and Technology Demonstration (RTD)
Mission.
H. Yasuda, M. Suzuki, K. Ando, K.
Fujitaka
Simulation of the low-Earth-orbit dose rates using secondary
radiations from the HZE particles at NIRS-HIMAC.
J.C. Sutherland, D.C. Monteleone,
J.G. Trunk
The Integrating Ion Imager: A Device for Determining Heavy Ion
Doses During Irradiations.
P. Scampoli, M. Casale, M.
Durante, G. Grossi, M. Pugliese, G. Gialanella
Cell Inactivation by Beryllium, Boron and Carbon Ions at the
Low-energy Irradiation Facility of the Naples University.
J. de Boer, J. Besserer, M.
Moosburger, P. Quicken, P. Bilski, T. Kwiecien, P. Olko
Dosimetry of Low-Energy Protons on the Vertical-Beam Facility at
the Munich Accelerator.
M. Fromm, F. Vaginay, D. Pusset,
G. Meesen, A. Chambaudet, A. Poffijn
3-D Confocal Microscopy of Etched Nuclear Tracks in CR-39.
Biophysical models
A.A. Edwards
RBE of Radiations in Space and the Implication, for Space Travel.
A.L. Ponomarev, F.A. Cucinotta,
R.K. Sachs, D.J. Brenner
Monte Carlo Predictions of DNA Fragment-Size Distributions for
Large Sizes after HZE Particle Irradiation.
S.B. Curtis, E.G. Luebeck, W.D.
Hazelton, S. H. Moolgavkar
The Role of Promotion in Carcinogenesis from Protracted High-LET
Exposure.
E. Gudowska-Nowak, A.
Kleczkowski, G. Kraft, E. Nasonova, S. Ritter, M. Scholz
Mathematical Models of Radiation-Induced Mitotic Delay: Time
Course Analysis and Statistics of Lesions.
R. Katz, F.A. Cucinotta, M.
Fromm, A. Chambaudet
Ion-Kill Dosimetry.
H. Yasuda, T. Komiyama, K.
Fujitaka
Probability of hippocampus cell hits by high-LET space radiation
in a low-Earth-orbit mission (STS-91).
M.V. Lokajic /ek, T. C/echák, L.
Judas, J. Kluson
/, V. Kundrát, K. Prokeš
Inactivation of individual cells by divers ions at different LET
values.
G. De Angelis, M. Caldora, M.
Santaquilani, R. Scipione, A. Verdecchia
Radiation-induced biological effects on crew members: a combined
analysis on atmospheric flight personnel.
S. Chauvie, R. Cirio, M. Donetto,
F. Marchetto, C. Peroni
A Monte Carlo Model for Cell-Cycle Kinetics in Charged particle
Irradiation.
R. Schulte, V. Bashkirov, S.
Shchemelinin, G. Garty, R. Chechik, A. Breskin
Modeling of radiation action based on nanodosimetric event
spectra.
R.D. Esposito, M. Durante, G.
Gialanella, G. Grossi, M. Pugliese, P. Scampoli, T.D. Jones
A model of radiation-induced myelopoiesis in space.
In vivo studies
A.L. Brooks, S. Bao, K.
Rithidech, W.B. Chrisler, L.A. Couch, L.A. Braby
Induction and Repair of HZE Induced Cytogenetic Damage.
A. Becciolini, S. Porciani, A.
Lanini, M. Balzi, P. Faraoni
Proposal for biochemical dosimeter for prolonged space flights.
S. Porciani, A. Lanini, M. Balzi,
P. Faraoni, A. Becciolini
Polyamines as biochemical indicators of radiation injury.
P.Y. Chang, N. Kanazawa, L.
Lutze-Mann, R. Winegar
HZE Particle Radiation Induces Tissue-specific and M53-dependent
Mutagenesis in Transgenic Animals.
F. Yatagai, T. Nohmi, M.
Kusakabe, K. Masumura, A. Yoshiki, H. Yamaguchi, T. Kurobe, K.
Kuniya, F. Hanaoka, Y. Yano
Mutation Induction by heavy-ion irradiation of gpt D transgenic
mice.
F.J. Burns, P. Zhao, G. Xu, N.
Roy, C. Loomis
Fibroma Induction in Rat Skin Following Single or Multiple Doses
of 1.0 GeV/nucleon 56 Fe Ions from the Brookhaven Alternating
Gradient Synchrotron (AGS).
Central nervous system
B.M. Rabin, B. Shukitt-Hale, J.A.
Joseph, N. Denissova
Effects of exposure to 56
Fe particles on the acquisition
of a conditioned place preference in rats.
Cellular and molecular biology
E. Nasonova, S. Ritter, E.
Gudowska-Novak, G. Kraft
High-LET-induced chromosomal damage: time-dependent expression.
B.M. Sutherland, P.V. Bennett, H.
Schenk, O. Sidorkina, J. Laval, J. Trunk, D. Monteleone, J.
Sutherland
Clustered DNA Damages Induced by High and Low LET Radiation,
Including Heavy Ions.
N. Cheong, Z.-C. Zeng, Y. Wang,
G. Iliakis
Evidence for factors modulating radiation-induced G2-delay:
potential application as radioprotectors.
C. Baumstark-Khan, C.E. Hellweg,
M. Palm, G. Horneck
Enhanced Green Fluorescent Protein (EGFP) for Space Radiation
Research using Mammalian Cells in the International Space
Station.
T. Ohnishi, A. Takahashi, K.
Ohnishi, M. Yonezawa
Tumor suppressor p53 response is blunted by low-dose-rate
radiation.
S. Brons, B. Jakob, G.
Taucher-Scholz, G. Kraft
Heavy ion production of single- and double-strand breaks in
plasmid DNA in aqueous solution.
M. Belli, V. Dini, G. Esposito,
P. Micera, O. Sapora, C. Signoretti, G. Simone, B. Stenerlöw,
M.A. Tabocchini
DNA fragmentation induced in K562 cells by nitrogen ions.
K. George, H. Wu, V. Willingham,
F.A. Cucinotta
The Effect of Space Radiation on the Induction of Chromosome
Damage.
T. Kawata, M. Durante, K. George,
Y. Furusawa, E. Gotoh, N. Takai, H. Wu, F.A. Cucinotta
Kineticts of chromatid break repair in G2-human fibroblasts
exposed to low- and high-LET radiation.
H. Wu, K. George, V. Willingham,
F.A. Cucinotta
Comparison of chromosome aberration frequencies in pre- and
post-flight astronaut lymphocytes irradiated in vitro with gamma rays.
A. Francesconi, E. Del Terra, A.
Meli, F.S. Ambesi-Impiombato
Standardization of the comet assay technique on FRTLC-5 Cells.
S. Gauny, C. Wiese, A. Kronenberg
Mechanisms of mutagenesis in human cells exposed to 55 MeV
protons.
A. Grosovsky, H. Bethel, K.
Parks, L. Ritter, C. Giver, S. Gauny, C. Wiese, A. Kronenberg
Genomic instability in human lymphoid cells exposed to 1 GeV/amu
Fe ions.
G. Palumbo, L. Varriale, V. Paba,
A. Sasso, E. Crescenzi, G. Gialanella, G. Grossi, M.G. Pugliese,
P. Scampoli
Effect of space radiation on expression of apoptosis-related
genes in endometrial cells: a preliminary study.
M.P.J. McNamara, K.A. Bjornstad,
P.Y. Chang, W. Chou, S.J. Lockett, E.A. Blakely
Modulation of Lens Cell Adhesion Molecules by Particle Beams.
Space Radiation Research in Italy
P. Spillantini, F. Taccetti, P.
Papini, L. Rossi, M. Casolino
Radiation shielding of astronauts in interplanetary flights: the
CREAM surveyor to Mars and the magnetic lens system for a
spaceship.
L. Narici, V. Bidoli, M.
Casolino, M.P. De Pascale, G. Furano, I. Modena, A. Morselli, P.
Picozza, E. Reali, R. Sparvoli, S. Licoccia, P. Romagnoli, E.
Traversa, W.G. Sannita, A. Loizzo, A. Galper, A. Khodarovich,
M.G. Korotkov, A. Popov, N. Vavilov, S. Avdeev, V.P. Salnitskii,
O.I. Shevchenko, V.P. Petrov, K.A. Trukhanov, M. Boezio, W.
Bonvicini, A. Vacchi, N. Zampa, R. Battiston, G. Mazzenga, M.
Ricci, P. Spillantini, G. Castellini, P. Carlson, C. Fuglesang
The ALTEA facility on the International Space Station.
G. De Angelis, M. Caldora, M.
Santaquilani, R. Scipione, A. Verdecchia
Radiation exposure of civilian airline crew members and
associated biological effects due to the atmospheric ionizing
radiation environment.
E. Del Terra, A. Francesconi, A.
Meli, F.S. Ambesi-Impiombato
Radiation-dependent apoptosis on cultured thyroid cells.
P. Mosesso, M. Schuber, D. Seibt,
C. Schmitz, M. Fiore, A. Schinoppi, S. Penna, F. Palitti
X-ray-induced chromosome aberrations in human lymphocytes in vitro are potentiated under simulated microgravity
conditions (clinostat).
G. Angelini, P. Ragni, D.
Esposito, P. Giardi, M.L. Pompili, R. Moscardelli, M.T. Giardi
A device to study the effect of space radiation on photosyntetic
organisms.
M. Durante
Influence of the shielding on
the space radiation biological effectiveness.
A. Ottolenghi, F. Ballarini, M.
Biaggi
Mechanistic bases for modelling space radiation risk and planning
radiation protection of astronauts.
M. Belli
An overview of recent charged-particle radiation biology in
Italy.
Radiation Research for the International Space Station
G. Reitz
European Dosimetry Activities for the ISS.
G.D. Badhwar
Radiation Measurements on the International Space Station.
K. Ando
High LET radiobiology at NIRS-current status and future plan.