Advertisement
Letter to the Editor| Volume 29, ISSUE 2, P221-223, March 2013

The impact of early life exposure to diagnostic and therapeutic radiation on childhood cancer risk

  • Yong Jian Ju
    Affiliations
    Department of Radiation Therapy, The First People's Hospital of Nantong, No. 6 North Haierxiang Road, 226001 Nantong, Jiangsu Province, People's Republic of China
    Search for articles by this author
  • Li Qing Du
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Jia Cao
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Yan Wang
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Xu Dong Miao
    Affiliations
    Department of Radiation Therapy, The First People's Hospital of Nantong, No. 6 North Haierxiang Road, 226001 Nantong, Jiangsu Province, People's Republic of China
    Search for articles by this author
  • Hong Wang
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Feng Hua Chen
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Fei Yue Fan
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
  • Gao Ren Wang
    Correspondence
    Corresponding author.
    Affiliations
    Department of Radiation Therapy, The First People's Hospital of Nantong, No. 6 North Haierxiang Road, 226001 Nantong, Jiangsu Province, People's Republic of China
    Search for articles by this author
  • Qiang Liu
    Correspondence
    Corresponding author.
    Affiliations
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, 238, Baidi Road, 300192 Tianjin, People's Republic of China
    Search for articles by this author
      As is commonly known, radiological protection of paediatric and pregnant patients exposed to medical diagnostic and therapeutic radiation has always received special attention. This is because children, embryos and foetuses have higher radiation sensitivities, and they exhibit an increased likelihood of developing radiation-induced cancer over their lives compared with people who are exposed to radiation as adults [
      • Streffer C.
      • Shore R.
      • Konermann G.
      • Meadows A.
      • Uma Devi P.
      • Preston Withers J.
      • et al.
      Biological effects after prenatal irradiation (embryo and fetus). A report of the International Commission on Radiological Protection.
      ,
      • Muhogora W.E.
      • Ahmed N.A.
      • Alsuwaidi J.S.
      • Beganovic A.
      • Ciraj-Bjelac O.
      • Gershan V.
      • et al.
      Paediatric CT examinations in 19 developing countries: frequency and radiation dose.
      ]. Considering the potential risk of stochastic effects (i.e., incurring cancer or heritable effects) in children, the IAEA (International Atomic Energy Agency) and the ICRP (International Commission on Radiological Protection) have paid particular attention to medical radiation exposure in children.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Physica Medica: European Journal of Medical Physics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Streffer C.
        • Shore R.
        • Konermann G.
        • Meadows A.
        • Uma Devi P.
        • Preston Withers J.
        • et al.
        Biological effects after prenatal irradiation (embryo and fetus). A report of the International Commission on Radiological Protection.
        Ann ICRP. 2003; 33: 5-206
        • Muhogora W.E.
        • Ahmed N.A.
        • Alsuwaidi J.S.
        • Beganovic A.
        • Ciraj-Bjelac O.
        • Gershan V.
        • et al.
        Paediatric CT examinations in 19 developing countries: frequency and radiation dose.
        Radiat Prot Dosim. 2010; 140: 49-58
        • Rajaraman P.
        • Simpson J.
        • Neta G.
        • Berrington de Gonzalez A.
        • Ansell P.
        • Linet M.S.
        • et al.
        Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study.
        BMJ. 2011; 342: d472
        • ICRP
        Recommendations of the International Commission on Radiological Protection.
        Ann ICRP. 2007; 37 ([ICRP Publication 103])
        • Wrixon A.D.
        New ICRP recommendations.
        J Radiol Prot. 2008; 28: 161-168
        • Münter M.W.
        • Wengenroth M.
        • Fehrenbacher G.
        • Schardt D.
        • Nikoghosyan A.
        • Durante M.
        • et al.
        Heavy ion radiotherapy during pregnancy.
        Fertil Steril. 2010; 94: 2329.e5-2329.e7
        • Kal H.B.
        • Struikmans H.
        Radiotherapy during pregnancy: fact and fiction.
        Lancet Oncol. 2005; 6: 328
        • Friedman D.L.
        • Whitton J.
        • Leisenring W.
        • Mertens A.C.
        • Hammond S.
        • Stovall M.
        • et al.
        Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study.
        J Natl Cancer Inst. 2010; 102: 1083-1095
        • Newhauser W.D.
        • Durante M.
        Assessing the risk of second malignancies after modern radiotherapy.
        Nat Rev Cancer. 2011; 11: 438-448

      Linked Article