Abstract
High-energy proton microscopy provides unique capabilities in penetrating radiography
including the combination of high spatial resolution and field-of-view, dynamic range
of density for measurements, and reconstructing density variations to less than 1%
inside volumes and in situ environments. We have recently proposed to exploit this novel proton radiography
technique for image-guided stereotactic particle radiosurgery. Results of a first
test for imaging biological and tissue-equivalent targets with high-energy (800 MeV)
proton microscopy are presented here. Although we used a proton microscope setup at
ITEP (Moscow, Russia) optimized for fast dynamic experiments in material research,
we could reach a spatial resolution of 150 μm with approximately 1010 protons per image. The potential of obtaining high-resolution online imaging of the
target using a therapeutic proton beam in the GeV energy region suggests that high-energy
proton microscopy may be used for image-guided proton radiosurgery.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Physica Medica: European Journal of Medical PhysicsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Particle therapy and treatment of cancer.Lancet Oncol. 2006; 7: 676-685
- Charged particles in radiation oncology.Nat Rev Clin Oncol. 2010; 7: 37-43
- Vision 20/20: proton therapy.Med Phys. 2009; 36: 556-568
- Emerging technologies in proton therapy.Acta Oncol. 2011; 50: 838-850
- Particle radiation therapy using proton and heavier ion beams.J Clin Oncol. 2007; 25: 953-964
- Heavy-ion tumor therapy: physical and radiobiological benefits.Rev Mod Phys. 2010; 82: 383-425
- Physical basis of radiation protection in space travel.Rev Mod Phys. 2011; 83: 1245-1281
- The future of heavy-ion science in biology and medicine.Radiat Res. 1985; 103: 1-33
- 1000 MeV proton therapy facility at Petersburg nuclear physics institute synchrocyclotron.J Phys. 2006; 41: 424-432
- Sensitivity study of proton radiography and comparison with kV and MV X-ray imaging using GEANT4 Monte Carlo simulations.Phys Med Biol. 2011; 56: 2407-2421
- An 800-MeV proton radiography facility for dynamic experiments.Nucl Instrum Meth. 1999; A424: 84-91
- Proton radiography and accurate density measurements: a window into shock wave processes.Phys Rev. 2008; B77: 220101
- Magnifying lenses for 800 MeV proton radiography.Rev Sci Instrum. 2011; 82: 103709
Proceedings of the 2011 High-Energy Proton Microscopy Workshop. Los Alamos, USA. Available online at: http://lansce.lanl.gov/proton%20microscopy/index.shtml.
- The FAIR start.Nucl Phys. 2011; A855: 506-509
- Proton microscopy at FAIR.AIP Conf Proc. 2009; 1195: 667-670
- Dosimetry techniques for narrow proton beam radiosurgery.Phys Med Biol. 1999; 44: 2789-2801
- Application of TWAC beams for diagnostics of fast processes.Atom Energ. 2008; 104: 99
- Diagnostics of fast processes by charged particle beams at TWAC–ITEP accelerator–storage facility.Tech Phys Lett. 2010; 36: 177
- Proton radiography.Science. 1968; 160: 913-914
- Density and spatial resolution of proton radiography using a range modulation technique.Phys Med Biol. 2008; 53: 5461-5468
- First proton radiography of an animal patient.Med Phys. 2004; 31: 1046-1051
- Nano-imaging of single cells using STIM.Nucl Instr Meth. 2007; B260: 124-129
- In-air scanning transmission ion microscopy of cultured cancer cells.Nucl Instr Meth. 2006; B181: 475-479
- Innovations in image-guided radiotherapy.Nat Rev Cancer. 2007; 7: 949-960
- Particle therapy for noncancer diseases.Med Phys. 2012; 39: 1716-1727
Article info
Publication history
Published online: April 03, 2012
Accepted:
March 5,
2012
Received in revised form:
March 1,
2012
Received:
January 19,
2012
Identification
Copyright
© 2012 Associazione Italiana di Fisica Medica. Published by Elsevier Inc. All rights reserved.
