Abstract
Non-invasive quantitative measurements are useful for clinical study as these are
simple and pain-free procedures. A new non-invasive semi-automatic quantitative measurement
method, the improved brain uptake ratio (IBUR) method using 99mTc-ECD SPECT, has recently been reported. If an automatic ROI setting algorithm could
be developed to determine the input function for the IBUR method, analysis of regional
cerebral blood flow (rCBF) can be completed within a few min without recourse to complex
techniques, through a fully automatic rCBF analysis program. The purpose of this study
was to develop an automatic input function determination program for 99mTc-ECD non-invasive cerebral blood flow quantification and to confirm the feasibility
of use of this program.
The images of 15 consecutive patients who underwent both 99mTc-ECD chest RI angiography and SPECT examinations were used for development of the
automatic arterial input function program. The images of 69 consecutive patients were
used for validation of the program.
The coincidence ratio between the ROI automatic method and the manual setting method
was 98%. The mean difference in the ROI location was ±6.4 mm in the X direction and ±8.6 mm in the Y direction. Individual rCBF values obtained using these independent techniques were
also reasonably well correlated (r = 0.95). The total time for the IBUR analysis using the automatic method is 2–3 min
as compared to 20–30 min for the current analysis method. This technique improves
the throughput of nuclear medical examinations.
Keywords
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Article info
Publication history
Published online: February 03, 2014
Accepted:
January 9,
2014
Received in revised form:
December 21,
2013
Received:
October 12,
2013
Identification
Copyright
© 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Inc. All rights reserved.
