- •CMOS APS flat panel detector successfully used for detection of phase contrast effects.
- •Higher image contrast in synchrotron planar and TS images compared to conventional mammography and TS.
- •Detail visibility enhanced by the edge enhancement caused by the FSP phase contrast.
The SYRMEP (SYnchrotron Radiation for MEdical Physics) beamline at Elettra is performing the first mammography study on human patients using free-space propagation phase contrast imaging. The stricter spatial resolution requirements of this method currently force the use of conventional films or specialized computed radiography (CR) systems. This also prevents the implementation of three-dimensional (3D) approaches. This paper explores the use of an X-ray detector based on complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology as a possible alternative, for acquisitions both in planar and tomosynthesis geometry.
Results indicate higher quality of the images acquired with the synchrotron set-up in both geometries. This improvement can be partly ascribed to the use of parallel, collimated and monochromatic synchrotron radiation (resulting in scatter rejection, no penumbra-induced blurring and optimized X-ray energy), and partly to phase contrast effects. Even though the pixel size of the used detector is still too large – and thus suboptimal – for free-space propagation phase contrast imaging, a degree of phase-induced edge enhancement can clearly be observed in the images.
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- Noise analysis of a CMOS active pixel sensor for tomographic mammography.in: Fifth International Workshop on System-on-Chip for Real-Time Applications, Proceedings. 2005: 167-171
- Medical Imaging 2008: physics of Medical Imaging, Pts 1–3)High resolution amplified pixel sensor architectures for large area digital mammography tomosynthesis – Art. no. 69133R. 6913. 2008: 9133-9139 (
- Digital x-ray tomosynthesis: current state of the art and clinical potential.Phys Med Biol. 2003; 48: R65-R106
- X-ray phase-contrast imaging: from pre-clinical applications towards clinics.Phys Med Biol. 2013; 58: R1-R35
- Synchrotron radiation Instrumentation, Pts 1 and 2)Synchrotron radiation mammography: clinical experimentation. 879. 2007: 1895-1898 (
- Clinical mammography at the SYRMEP beam line.Nucl Instrum Methods Phys Res Sect A-Accelerators Spectrom Detect Assoc Equip. 2007; 572: 237-240
- The mammography project at the SYRMEP beamline.Eur J Radiol. 2008; 68: S58-S62
- Low-dose phase contrast x-ray medical imaging.Phys Med Biol. 1998; 43: 2845-2852
- Experimental validation of a simple model capable of predicting the phase contrast imaging capabilities of any x-ray imaging system.Phys Med Biol. 2006; 51: 3015-3030
- The Dexela 2923 CMOS X-ray detector: a flat panel detector based on CMOS active pixel sensors for medical imaging applications.Nucl Instrum Methods Phys Res Sect A-Accelerators Spectrom Detect Assoc Equip. 2012; 689: 12-21
- X-ray performance evaluation of the Dexela CMOS APS X-ray detector using monochromatic synchrotron radiation in the mammographic energy range.in: Nuclear Science, IEEE Trans. 60. 2013: 3969-3980
- Proof-of-concept demonstration of edge-illumination x-ray phase contrast imaging combined with tomosynthesis.Phys Med Biol. 2014; 59: N1-N10
- European guidelines for quality assurance in breast cancer screening and diagnosis.4th ed. European Commission, Luxembourg, Office for Official Publications of the European Communities, 2006
- Dosimetry in diagnostic radiology: an international code of practice technical reports series no 457 (Vienna: IAEA) Vienna: IAEA: International Atomic Energy Agency (IAEA).2006
- Further factors for the estimation of mean glandular dose using the United Kingdom, European and IAEA breast dosimetry protocols.Phys Med Biol. 2009; 54: 4361-4372
- Glandular breast dose for monoenergetic and high-energy X-ray beams: Monte Carlo assessment.Radiology. 1999; 213: 23-37
- Estimation of mean glandular dose for breast tomosynthesis: factors for use with the UK, European and IAEA breast dosimetry protocols.Phys Med Biol. 2011; 56: 453-471
- Quantitative comparison between two phase contrast techniques: diffraction enhanced imaging and phase propagation imaging.Phys Med Biol. 2005; 50: 709-724
- Modelling of the effect of organ motion combined with field parameters on the received dose to a target region.Radiother Oncol. 2005; 76: S156-S157
- Comparison of breast doses for digital tomosynthesis estimated from patient exposures and using PMMA breast phantoms.in: Maidment A.A. Bakic P. Gavenonis S. Breast imaging. Springer Berlin Heidelberg, 2012: 316-321
Published online: December 11, 2014
Accepted: November 10, 2014
Received in revised form: October 7, 2014
Received: June 30, 2014
© 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Inc. All rights reserved.