- •Flat and surface applicators of a low X-ray miniature accelerator were characterized.
- •Characterization was made in standard and more clinical conditions for skin treatment.
- •Flat and surface applicators have different behaviors.
- •Surface applicators can be used to treat superficial lesions.
- •Close contact between applicator and skin must be achieved.
This study aims at characterizing the dosimetric behavior of an INTRABEAM® miniature accelerator equipped with flat and surface applicators, converting the spherical dose distribution into a flat one.
Dosimetric characterization was carried out in two steps. Firstly characterization was made in standard conditions for dermatologic applications, which is with the applicator directly on contact with the skin. Secondly, characterization was made in more clinical conditions, such as obliquities and heterogeneities.
Behaviors of flat and surface applicators are different. Dose distribution for surface applicators is uniform at surface, whereas for flat applicator the maximum homogeneity is shown at a particular depth in water. Some results are different from previously published studies due to differences in the X-ray source design. The study showed that in the absence of a perfect contact between the applicator and the skin of the patient, there is a dose distribution spread on the edge of the irradiation field where the contact is not made. Dose loss due to lack of backscatter radiations is significant. By contrast, influence of a denser material behind the measurement point has no significant influence on the dose at this point. Thickness of tissue treated with flat and surface applicators is only a few millimeters, depending on the applicator's size, making these applicators ideal for superficial lesions, compared to high energy electrons and iridium brachytherapy.
The INTRABEAM® miniature accelerator equipped with surface applicators is a reliable way of treating superficial cutaneous malignancies.
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- The epidemiology of skin cancer.Br J Dermatol. 2002; 146: 1-6https://doi.org/10.1046/j.1365-2133.146.s61.2.x
- Radiation therapy in the management of cutaneous malignancies.Clin Dermatol. 2001; 19: 348-353
- External irradiation of epithelial skin cancer.Int J Radiat Oncol Biol Phys. 1990; 19: 235-242
- Use of low-energy X-rays in the treatment of superficial nonmelanomatous skin cancers.Cancer Invest. 2003; 21: 355-362
- Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas.J Am Acad Dermatol. 2005; 53: 993-1001
- Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients.J Am Acad Dermatol. 2012; 67: 1235-1241
- Brachytherapy in lip carcinoma: long-term results.Int J Radiat Oncol Biol Phys. 2011; 81: e839-e843https://doi.org/10.1016/j.ijrobp.2010.10.031
- Retrospective analysis of local control and cosmetic outcome of 147 periorificial carcinomas of the face treated with low-dose rate interstitial brachytherapy.Int J Radiat Oncol Biol Phys. 2011; 81: 726-731https://doi.org/10.1016/j.ijrobp.2010.05.061
- The use of brachytherapy in the treatment of nonmelanoma skin cancer: a review.J Am Acad Dermatol. 2011; 65: 377-388
- Surgical treatment of nonmelanoma skin cancer.AORN J. 2000; 71: 550-564
- Intraoperative Radiotherapy (IORT) for breast cancer using the IntraBeam TM system.Tumori. 2005; 91: 339-345
- Accelerated partial breast irradiation: initial experience with the intrabeam system.Surg Oncol. 2011; 20: 73-79
- Dosimetry measurements with an intra-operative x-ray device.Phys Med Biol. 2010; 55: N359
- A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report.J Appl Clin Med Phys. 2014; 15: 4502
- Dosimetric characteristics of INTRABEAM® flat and surface applicators.Transl Cancer Res. 2014; 3: 106-111
- Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams.Med Phys. 2012; 39: 7412-7417https://doi.org/10.1118/1.4767770
- Comparison of Gafchromic EBT2 and EBT3 films for clinical photon and proton beams.Med Phys. 2012; 39: 5257-5262
- Suitability of radiochromic films for dosimetry of very-low energy X-rays.J Appl Clin Med Phys. 2009; 10: 2957
- Radiochromic film dosimetry: past, present, and future.Phys Med PM Int J Appl Phys Med Biol Off J Ital Assoc Biomed Phys. 2011; 27: 122-134https://doi.org/10.1016/j.ejmp.2010.10.001
- Multichannel film dosimetry with nonuniformity correction.Med Phys. 2011; 38: 2523-2534
- Absorbed dose determination in photon and electron beams: an international code of practice.Intl Atomic Energy Agency, 1987
Published online: February 13, 2015
Accepted: January 20, 2015
Received in revised form: January 17, 2015
Received: November 16, 2014
© 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Inc. All rights reserved.