Highlights
- •Tumor monitoring using prompt gamma ray during BNCT.
- •Acquisition of single prompt gamma image using insertable collimator from PET.
- •Prompt gamma ray image reconstruction using OSEM algorithm.
- •Actual condition for BNCT in Monte Carlo simulation.
Abstract
We confirmed the feasibility of using our proposed system to extract two different
kinds of functional images from a positron emission tomography (PET) module by using
an insertable collimator during boron neutron capture therapy (BNCT). Coincidence
events from a tumor region that included boron particles were identified by a PET
scanner before BNCT; subsequently, the prompt gamma ray events from the same tumor
region were collected after exposure to an external neutron beam through an insertable
collimator on the PET detector. Five tumor regions that contained boron particles
and were located in the water phantom and in the BNCT system with the PET module were
simulated with Monte Carlo simulation code. The acquired images were quantitatively
analyzed. Based on the receiver operating characteristic (ROC) curves in the five
boron regions, A, B, C, D, and E, the PET and single-photon images were 10.2%, 11.7%,
8.2% (center region), 12.6%, and 10.5%, respectively. We were able to acquire simultaneously
PET and single prompt photon images for tumor regions monitoring by using an insertable
collimator without any additional isotopes.
Keywords
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Article info
Publication history
Published online: March 09, 2016
Accepted:
February 23,
2016
Received in revised form:
February 22,
2016
Received:
July 28,
2015
Identification
Copyright
© 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
