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Therapy region monitoring based on PET using 478 keV single prompt gamma ray during BNCT: A Monte Carlo simulation study

  • Joo-Young Jung
    Affiliations
    Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea
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  • Bo Lu
    Affiliations
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610-0385, United States
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  • Do-Kun Yoon
    Affiliations
    Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea
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  • Key Jo Hong
    Affiliations
    Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, United States
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  • HongSeok Jang
    Affiliations
    Department of Radiation Oncology, College of Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul 505, Republic of Korea
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  • Chihray Liu
    Affiliations
    Department of Radiation Oncology, University of Florida, Gainesville, FL 32610-0385, United States
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  • Tae Suk Suh
    Correspondence
    Corresponding author. Department of Biomedical Engineering, College of Medicine, Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea. Tel.: +82 2 2258 7232; fax: +82 2 2258 7506.
    Affiliations
    Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, Republic of Korea
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Published:March 09, 2016DOI:https://doi.org/10.1016/j.ejmp.2016.02.010

      Highlights

      • Tumor monitoring using prompt gamma ray during BNCT.
      • Acquisition of single prompt gamma image using insertable collimator from PET.
      • Prompt gamma ray image reconstruction using OSEM algorithm.
      • Actual condition for BNCT in Monte Carlo simulation.

      Abstract

      We confirmed the feasibility of using our proposed system to extract two different kinds of functional images from a positron emission tomography (PET) module by using an insertable collimator during boron neutron capture therapy (BNCT). Coincidence events from a tumor region that included boron particles were identified by a PET scanner before BNCT; subsequently, the prompt gamma ray events from the same tumor region were collected after exposure to an external neutron beam through an insertable collimator on the PET detector. Five tumor regions that contained boron particles and were located in the water phantom and in the BNCT system with the PET module were simulated with Monte Carlo simulation code. The acquired images were quantitatively analyzed. Based on the receiver operating characteristic (ROC) curves in the five boron regions, A, B, C, D, and E, the PET and single-photon images were 10.2%, 11.7%, 8.2% (center region), 12.6%, and 10.5%, respectively. We were able to acquire simultaneously PET and single prompt photon images for tumor regions monitoring by using an insertable collimator without any additional isotopes.

      Keywords

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      References

        • Ono K.
        • Kinashi Y.
        • Masunaga S.I.
        • Suzuki M.
        • Takagaki M.
        Electroporation increases the effect of borocaptate (10B-BSH) in neutron capture therapy.
        Int J Radiat Oncol Biol Phys. 1998; 42: 823-826
        • Barth R.F.
        • Grecula J.C.
        • Yang W.
        • Rotaru J.H.
        • Nawrocky M.
        • Gupta N.
        • et al.
        Combination of boron neutron capture therapy and external beam radiotherapy for brain tumors.
        Int J Radiat Oncol Biol Phys. 2004; 58: 267-277
        • Af Rosenschöld P.M.
        • Verbakel W.F.A.R.
        • Ceberg C.P.
        • Stecher-Rasmussen F.
        • Persson B.R.R.
        Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy.
        Med Phys. 2001; 28: 787-795
        • Kinashi Y.
        • Masunaga S.
        • Nagata K.
        • Suzuki M.
        • Takahashi S.
        • Ono K.
        A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus.
        Int J Radiat Oncol Biol Phys. 2007; 68: 508-514
        • Barth R.F.
        • Soloway A.H.
        • Goodman J.H.
        • Gahbauer R.A.
        • Gupta N.
        • Blue T.E.
        • et al.
        Boron neutron capture therapy of brain tumors: an emerging therapeutic modality.
        Neurosurgery. 1999; 44: 433-450
        • Kankaanranta L.
        • Seppälä T.
        • Koivunoro H.
        • Saarilahti K.
        • Atula T.
        • Collan J.
        • et al.
        Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: final analysis of a phase I/II trial.
        Int J Radiat Oncol Biol Phys. 2012; 82: e67-75
        • Nievaart V.A.
        • Légràdy D.
        • Moss R.L.
        • Kloosterman J.L.
        • van der Hagen T.H.J.J.
        • Van Dam H.
        Application of adjoint Monte Carlo to accelerate simulations of mono-directional beams in treatment planning for Boron Neutron Capture Therapy.
        Med Phys. 2007; 34: 1321-1335
        • Huang L.C.S.
        • Hsieh W.Y.
        • Chen J.Y.
        • Huang S.C.
        • Chen J.K.
        • Hsu M.H.
        Drug delivery system design and development for boron neutron capture therapy on cancer treatment.
        Appl Radiat Isot. 2014; 88: 89-93
        • Coderre J.A.
        • Turcotte J.C.
        • Riley K.J.
        • Binns P.J.
        • Harling O.K.
        • Kiger W.S.
        Boron neutron capture therapy: cellular targeting of high linear energy transfer radiation.
        Technol Cancer Res Treat. 2003; 2: 355-375
        • Hopewell J.W.
        • Gorlia T.
        • Pellettieri L.
        • Giusti V.
        • H-Stenstam B.
        • Sköld K.
        Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: an assessment of clinical potential.
        Appl Radiat Isot. 2011; 69: 1737-1740
        • Kato I.
        • Fujita Y.
        • Maruhashi A.
        • Kumada H.
        • Ohmae M.
        • Kirihata M.
        Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies.
        Appl Radiat Isot. 2009; 67: S37-42
        • Tanaka H.
        • Sakurai Y.
        • Suzuki M.
        • Takata T.
        • Masunaga S.
        • Kinashi Y.
        Improvement of dose distribution in phantom by using epithermal neutron source based on the Be (p, n) reaction using a 30MeV proton cyclotron accelerator.
        Appl Radiat Isot. 2009; 67: S258-61
        • Katabuchi T.
        • Hales B.
        • Hayashizaki N.
        • Igashira M.
        • Khan Z.
        • Kobayashi T.
        • et al.
        Feasibility study on pinhole camera system for online dosimetry in boron neutron capture therapy.
        Appl Radiat Isot. 2014; 88: 139-142
        • Ishikawa M.
        • Kobayashi T.
        • Sakurai Y.
        • Kanda K.
        Optimization technique for a prompt gamma-ray SPECT collimator system.
        J Radiat Res. 2001; 42: 387-400
        • Kobayashi T.
        • Sakurai Y.
        • Ishikawa M.
        A noninvasive dose estimation system for clinical BNCT based on PG-SPECT-Conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors.
        Med Phys. 2000; 27: 2124-2132
        • Somer E.J.
        • Pike L.C.
        • Marsden P.K.
        Recommendations for the use of PET and PET–CT for radiotherapy planning in research projects.
        Br J Radiol. 2012; 85: e544-8
        • Yoon D.K.
        • Jung J.Y.
        • Hong K.J.
        • Suh T.S.
        Tomographic image of prompt gamma ray from boron neutron capture therapy: a Monte Carlo simulation study.
        Appl Phys Lett. 2014; 104: 083521
        • Kimble T.
        • Chou M.
        • Chai B.H.
        Scintillation properties of LYSO crystals.
        IEEE Nucl Sci Symp Conf Rec (1997). 2002; 3: 1434-1437
        • Fotakis M.
        • Athanasopoulou E.M.
        • Psarrakos K.
        • Economou I.
        Radiation doses to paediatric patients up to 5 years of age undergoing micturating cystourethrography examinations and its dependence on patient age: a Monte Carlo study.
        Br J Radiol. 2003; 83: 812-817
        • Naswa N.
        • Kumar A.
        • Sharma P.
        • Bal C.
        • Malhotra A.
        • Kumar R.
        Imaging carotid body chemodectomas with 68Ga-DOTA-NOC PET-CT.
        Br J Radiol. 2012; 85: 1140-1145
        • Yip W.M.
        • Pang S.Y.
        • Yim W.S.
        • Kwok C.S.
        ROC curve analysis of lesion detectability on phantoms: comparison of digital spot mammography with conventional spot mammography.
        Br J Radiol. 2001; 74: 621-628
        • Swensson R.G.
        • King J.L.
        • Gur D.
        A constrained formulation for the receiver operating characteristic (ROC) curve based on probability summation.
        Med Phys. 2001; 28: 1597-1609