Highlights
- •MC calculations were used to assess neutron doses to healthy organs.
- •Lateral incidences induce more neutron doses than the anterior–superior incidence.
- •Impact of some irradiation parameters on neutron doses changes with beam incidence.
- •Investigations on internal neutron fluence and doses were carried out.
- •Beam incidence impacts the fluence and energy of neutrons reaching the patient.
Abstract
Purpose
Methods
Results
Conclusion
Keywords
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Physica Medica: European Journal of Medical PhysicsReferences
- Proton therapy – a systematic review of clinical effectiveness.Radiother Oncol. 2007; 83: 123-132
- Late effects of early childhood cancer therapy.Br J Cancer. 1992; 66: 92-95
- Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age.Int J Radiat Oncol Biol Phys. 2008; 72: 228-235
- Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans.Radiother Oncol. 2011; 98: 87-92
- Secondary dose exposures during 200 MeV proton therapy.Radiat Prot Dosimetry. 1997; 70: 441-444
- Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field.Nucl Instrum Methods Phys Res. 2002; 476: 429-434
- Scattered neutron dose equivalent to a fetus from proton therapy of the mother.Radiat Phys Chem. 2004; 71: 997-998
- Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams.Phys Med Biol. 2009; 54: 2259-2275
- Neutron equivalent doses and associated lifetime cancer incidence risks for head and neck and spinal proton therapy.Phys Med Biol. 2009; 54: 4907-4926
- The risk of developing a second cancer after receiving craniospinal proton irradiation.Phys Med Biol. 2009; 54: 2277-2291
- Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams.Phys Med Biol. 2005; 50: 3859-3873
- Neutron scattered dose equivalent to a fetus from proton radiotherapy of the mother.Med Phys. 2006; 33: 2479-2490
- Monte Carlo study of neutron dose equivalent during passive scattering proton therapy.Phys Med Biol. 2007; 52: 4481-4496
- Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer.Phys Med Biol. 2008; 53: 1677-1688
- Assessment of organ specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms.Phys Med Biol. 2008; 53: 693-717
- Secondary neutron doses for several beam configurations for proton therapy.Int J Radiat Oncol Biol Phys. 2009; 74: 260-265
- Secondary neutron doses received by paediatric patients during intracranial proton therapy treatments.J Radiol Prot. 2014; 34: 279-296
- The descriptive epidemiology of craniopharyngioma.J Neurosurg. 1998; 89: 547-551
- Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas.Int J Radiat Oncol Biol Phys. 2012; 82: 643-652
- Relative biological effectiveness (RBE) values for proton beam therapy.Int J Radiat Oncol Biol Phys. 2002; 53: 407-421
Pelowitz DB. MCNPX user’s manual, version 2.6.0. Report: LA-CP-07-1473. USA: Los Alamos National Laboratory; 2008.
- Neutron, proton, and photonuclear cross-sections for radiation therapy and radiation protection.Radiat Environ Biophys. 1998; 37: 235-242
- Cross-section evaluations to 150 MeV for accelerator-driven systems and implementation in MCNPX.Nucl Sci Eng. 1999; 131: 293-328
- Nuclear data for accelerator-driven systems.Prog Nucl Energy. 2001; 38: 179-219
- Low-energy intranuclear cascade calculation.Phys Rev. 1963; 131: 1801-1821
Dresner L. EVAP: a fortran program for calculating the evaporation of various particles from excited compound nuclei. Report: ORNL-TM-196. USA: Oak Ridge National Laboratory; 1962.
- Spread-out Bragg peak and monitor units calculation with the Monte Carlo code MCNPX.Med Phys. 2007; 34: 680-688
- Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams.Phys Med Biol. 2005; 50: 5229-5249
- Monte Carlo simulation of a proton therapy beam line for intracranial treatments.Radioprotection. 2013; 48: 317-339
Bonfrate A, Farah J, De Marzi L, Delacroix S, Constant E, Hérault J, et al. Monte Carlo modeling of various passive scattering proton therapy beam line configurations and experimental validation. (Radioprotection, submitted 2015).
- Monte Carlo modeling of proton therapy installations: a global experimental method to validate secondary neutron dose calculations.Phys Med Biol. 2014; 59: 2747-2765
- Hybrid computational phantoms of the male and female newborn patient: NURBS-based whole-body models.Phys Med Biol. 2007; 52: 3309-3333
- The UF family of reference hybrid phantoms for computational radiation dosimetry.Phys Med Biol. 2010; 55: 339-363
- Analytic estimates of secondary neutron dose in proton therapy.Phys Med Biol. 2010; 55: 7509-7522
- Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems.Med Phys. 2015; 42: 2572-2584
- Relative Biological Effectiveness (RBE), Quality Factor (Q), and Radiation Weighting Factor (wR).ICRP Publ 92 Ann ICRP, 2003 (33(4))
- Secondary neutron doses in a compact proton therapy system.Radiat Prot Dosimetry. 2014; 161: 368-372
- The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publ. 103.Ann ICRP. 2007; 37: 2-4