Highlights
- •The performance of a pre-clinical SPECT/CT system for 188Re imaging is investigated.
- •Image quality and image quantification is assessed for two multi-pinhole collimators.
- •Monte-Carlo simulations of the pre-clinical SPECT system were performed.
- •Image quality and image quantification of 188Re was comparable to 99mTc performance.
- •188Re images suffered from higher noise due to large number of down-scatter photons.
Abstract
Purpose
The goal of this study was to investigate the performance of a pre-clinical SPECT/PET/CT
system for 188Re imaging.
Methods
Phantom experiments were performed aiming to assess the characteristics of two multi-pinhole
collimators: ultra-high resolution collimator (UHRC) and high-energy ultra high resolution
collimator (HE-URHC) for imaging 188Re. The spatial resolution, image contrast and contrast-to-noise ratio (CNR) were
investigated using micro-Jaszczak phantoms. Additionally, the quantification accuracy of 188Re images was evaluated using two custom-designed phantoms. The 188Re images were compared to those obtained with 99mTc (gold standard); the acquired energy spectra were analyzed and Monte-Carlo simulations
of the UHRC were performed. To verify our findings, a C57BL/6-mouse was injected with 188Re-microspheres and scanned with both collimators.
Results
The spatial resolution achieved in 188Re images was comparable to that of 99mTc. Acquisitions using HE-UHRC yielded 188Re images with higher contrast and CNR than UHRC. Studies of quantitative accuracy
of 188Re images resulted in <10% errors for both collimators when the activity was calculated
within a small VOI around the object of interest. Similar quantification accuracy
was achieved for 99mTc. However, 188Re images showed much higher levels of noise in the background. Monte-Carlo simulations
showed that 188Re imaging with UHRC is severely affected by down-scattered photons from high-energy
emissions. The mouse images showed similar biodistribution of 188Re-microspheres for both collimators.
Conclusions
VECTor/CT provided 188Re images quantitatively accurate and with quality comparable to 99mTc. However, due to large penetration of UHRC by high-energy photons, the use of the
HE-UHRC for imaging 188Re in VECTor/CT is recommended.
Keywords
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Article info
Publication history
Published online: December 19, 2016
Accepted:
November 14,
2016
Received in revised form:
October 10,
2016
Received:
August 17,
2016
Identification
Copyright
© 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
