Highlights
- •We used 51 previously administered VMAT plans to train a RapidPlan model.
- •Thirty RapidPlan based plans compared with 30 clinical manual optimization plans.
- •RapidPlan based plans were created by a single optimization without intervention.
- •The dose volume parameter values for the PTV were significantly similar.
- •Rectal and bladder doses in RapidPlan based plans were comparable to clinical plans.
Abstract
Purpose
This study evaluated whether RapidPlan based plans (RP plans) created by a single
optimization, are usable in volumetric modulated arc therapy (VMAT) for patients with
prostate cancer.
Methods
We used 51 previously administered VMAT plans to train a RP model. Thirty RP plans
were created by a single optimization without planner intervention during optimization.
Differences between RP plans and clinical manual optimization (CMO) plans created
by an experienced planner for the same patients were analyzed (Wilcoxon tests) in
terms of homogeneity index (HI), conformation number (CN), D95%, and D2% to planning target volume (PTV), mean dose, V50Gy, V70Gy, V75Gy, and V78Gy to rectum and bladder, monitor unit (MU), and multi-leaf collimator (MLC) sequence
complexity.
Results
RP and CMO values for PTV D95%, PTV D2%, HI, and CN were significantly similar (p < 0.05 for all). RP mean dose, V50Gy, and V70Gy to rectum were superior or comparable to CMO values; RP V75Gy and V78Gy were higher than in CMO plans (p < 0.05). RP bladder dose-volume parameter values (except V78Gy) were lower than in CMO plans (p < 0.05). MU values were RP: 730 ± 55 MU and CMO: 580 ± 37 MU (p < 0.05); and MLC sequence complexity scores were RP: 0.25 ± 0.02 and CMO: 0.35 ± 0.03 (p < 0.05).
Conclusions
RP plans created by a single optimization were clinically acceptable in VMAT for patient
with prostate cancer. Our simple model could reduce optimization time, independently
of planner’s skill and knowledge.
Keywords
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Article info
Publication history
Published online: July 10, 2017
Accepted:
June 29,
2017
Received in revised form:
June 27,
2017
Received:
March 29,
2017
Identification
Copyright
© 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
