Highlights
- •Radionuclide biodistribution template has been created as free resource for the community.
- •Can help with data organization, reporting, and innovation.
- •May be used to standardize information and improve integrity of published dosimetry research.
Abstract
Radionuclide absorbed-dose dosimetry is an active area of development and has the
potential to positively impact molecular radiotherapies. At present, many of the operations
required to perform dosimetry calculations are unstandardized and unestablished. While
the current methodology allows reasonable dosimetry estimates to be derived and published,
it can be difficult to understand, and reproduce, each others’ work. To help alleviate
this we have identified the collection of biodistribution information as a key step
in all internal dosimetry calculations, and present a template that can be used to
standardize its documentation and reporting.
A generalized biodistribution template entitled the IAEA Radiotracer Biodistribution
Template (IAEA RaBiT) has been built and distributed for users performing biodistribution
measurements in the community. The template enables robust recording of dosimetry-relevant
information through standardization of details and their format. It has been designed
to be simple and easy to use, and establish a structured recording of a common reference
point in dosimetry operations – biodistribution data documentation. Improved documentation
procedures may benefit organization of in house data, or be used to disseminate details
throughout the community – for example to supplement dosimetry related publications.
The standard format information may also enable the creation of new dosimetry related
tools and protocols and support robust population databases.
As dosimetry in nuclear medicine becomes more routinely applied in clinical applications,
we need to develop the infrastructure for robustly handling large amounts of these
data. Our IAEA RaBiT can be used as a standard format structure for data collection,
organization, and dissemination.
Graphical abstract
Graphical Abstract
Keywords
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References
- EANM dosimetry committee guidance document: good practice of clinical dosimetry reporting.Eur J Nucl Med Mol Imag. 2011; 38: 192-200
- Small data: a ubiquitous, yet untapped, resource for low-cost imaging innovation.J Nucl Med. 2017; 58: 198-200
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- OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine.J Nucl Med. 2005; 46: 1023-1027
Article info
Publication history
Published online: September 16, 2017
Accepted:
July 30,
2017
Received in revised form:
July 7,
2017
Received:
May 17,
2017
Identification
Copyright
© 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
