Highlights
- •The relative renal function is important in the primary assessment of renal diseases.
- •Both static (99mTc-DMSA) and dynamic (99mTc-DTPA) scintigraphies have been used to calculate the relative renal functions.
- •A positive correlation has been found between the two scanning methods.
- •Except GFR and renogram curves, it is suggested to use 99mTc‑DMSA since it is easy method and less expensive.
Abstract
Renal scintigraphy is an imaging method that uses small amount of radioactive materials
called radiotracers, a Gamma camera and a computer to evaluate kidney functions and
its anatomy. The present work reports the comparison of the relative renal functions
(RRF) calculated with technetium-99m dimercaptosuccinic acid (99mTc‑DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99mTc‑DTPA) for kidney patients of ages between 5 months and 71 years. A total of 50
patients including 29 male and 21 female has been selected and studied for renography.
The mean RRFs have been found to be 52.68 ± 23.63% and 47.32 ± 23.63% respectively
for the left and right kidneys with 99mTc-DMSA measurement. With 99mTc-DTPA the values are 52.74 ± 23.54% and 47.26 ± 23.54% for the same. In bivariate
correlation analysis, a significant positive correlation (r = 0.996, P < .001) has been found between the RRFs calculated with the two methods. Following
the patients’ diagnosis, in ANOVA test, no difference has been found between the RRFs
calculated for the left and right kidneys. In Bland-Altman plots, the mean difference
between the two methods has been found to be 0.1 and the correlation limit lies between
−4.3 and 4.2. According to the result obtained in the present work, both the 99mTc-DMSA and 99mTc-DTPA scanning methods provide almost the same RRF values. It is, therefore, always
not necessary to calculate the RRFs with both the methods. This study suggests that
99mTc-DMSA may be the primary choice for the evaluation of RRF, but if the glomerular
filtration rate (GFR) and renogram curve are required, 99mTc-DTPA can be the obvious selection.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Physica Medica: European Journal of Medical PhysicsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Comparison of split renal function measured by Tc-DTPA, Tc-MAG3, Tc-DMSA renal scintigraphies in pediatric age groups.Clin Rev Opin. 2011; 3: 20-25
- Split renal function measured by triphasic helical CT.Eur J Radiol. 2007; 61: 303-309
- Technetium-99m-EC and other potential new agents in renal nuclear medicine.Semin Nucl Med. 1999; 29: 91-101
- (99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors.Ann Nucl Med. 2010; 24: 189-195
- Renal nuclear medicine: a review.Vet Radiol Ultrasound. 1999; 40: 572-587
- Tubular reabsorption of technetium-99m-DMSA.J Nucl Med. 1995; 36: 1654-1658
- Renal radionuclides and in vitro quantitation.in: Sandler M.P. Coleman R.E. Patton J.A. Wackers F.J. Gottschalk A. Diagnostic nuclear medicine. 4th ed. Lippincott Williams & Wilkins, Philadelphia2003: 851-864
- Renal cortical scintigraphy in the diagnosis of acute pyelonephritis.Semin Nucl Med. 1992; 22: 98-111
- Quantitative analysis of 99mTc-DMSA during acute pyelonephritis for prediction of long-term renal scarring.J Nucl Med. 2004; 45: 285-289
- Evaluation of renal scars by technetium-labeled dimercaptosuccinic acid scan, intravenous urography, and ultrasonography: a comparative study.J Pediatr. 1992; 120: 399-403
- 99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function.Ann Nucl Med. 2001; 15: 179-190
- Comparison of the relative renal function calculated with 99mTc-diethylenetriaminepentaacetic acid and 99mTc-dimercaptosuccinic acid in children. World.J Nucl Med. 2014; 13: 149-153
- Dosimetry of 99mTc (DTPA, DMSA and MAG3) used in renal function studies of newborns and children.Appl Radiat Isot. 2017; (pii: S0969-8043(17)30130-6)
- Renal uptakes of 99mTc-MAG3, 99mTc-DTPA, and 99mTc-DMSA in rabbits with unilateral ureteral obstruction.Vivo. 2010; 24: 137-139
- Comparison of relative renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured with 99mTc-DMSA static Scintigraphy.Int Braz J Urol. 2006; 32: 405-409
- Quantitation of absolute and relative renal uptake using 99mTc-DMSA: sequential change in time and correlation with 99mTc-DTPA uptake.Kaku Igaku. 1990; 27: 237-242
Sinclair Patricia. Distance assisted training programme for nuclear medicine technologists, Regional Cooperative Agreement, International Atomic Energy Agency. In: Patterson HE, Hutton BF, editors. Renal Imaging Module 6, Unit 10; 2003. p. 58.
- Clinical renography: 25 years on.Eur J Nucl Med. 1996; 23: 1541-1546
- Renal handling of technetium-99m DMSA: evidence for glomerular filtration and peritubular uptake.J Nucl Med. 1989; 30: 1219-1223
- Measurement of relative renal function: a comparison of methods and assessment of reproducibility.Br J Radiol. 1987; 60: 861-864
Article info
Publication history
Accepted:
December 4,
2017
Received in revised form:
December 3,
2017
Received:
July 17,
2017
Identification
Copyright
© 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
