Highlights
- •We examined the point spread function of a cross-sectional Compton image.
- •The effect of the number of views was also examined.
- •The double Lorentzian function approximated the PSF well.
- •Insufficient views caused star-shaped artifacts, but did not degrade spatial resolution.
Abstract
Introduction
We have been developing a medical imaging technique using a Compton camera, which
is expected to reconstruct three-dimensional images. If the number of views is not
sufficient, star-shaped artifacts (streak artifacts) could arise in cross-sectional
images. Therefore, we estimated the point spread function (PSF) of cross-sectional
Compton images and the effect of the number of views by Monte Carlo simulations and
experimental studies.
Materials and methods
A cross-sectional Compton image was reconstructed using a dataset comprising 719 view
directions and PSF was analyzed using a radial distribution. The peak height, full
width at half maximum (FWHM), background (BG), and residual sum of squares (RSS) were
calculated from the obtained PSF. In addition, RSSs were plotted against the number
of views to estimate the required number to suppress star-shaped artifacts.
Results
There was no correlation found between the number of views and both FWHM (16 mm) and
peak/BG ratio (∼1 × 104). RSSs were reduced with the number of views and approached the minimum asymptotically.
Correlation was observed between the required number of views and the number of Compton
events used for image reconstruction.
Conclusion
We determined the PSF of cross-sectional Compton images and the effect of the number
of views on the images. The required number of views to suppress the star-shaped artifact
is related to the square root of the number of Compton events used to reconstruct
the image. From this study, we concluded that 21 or more views are required for clinical
purposes.
Keywords
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References
- Instrument description and performance of the Imaging Gamma-Ray Telescope COMPTEL aboard the Compton Gamma-Ray Observatory.Astrophys J Suppl Series. 1993; 86: 657
- Hitomi (ASTRO-H) X-ray astronomy satellite.J Astron Telesc Instrum. 2018; 4021402
Nakazawa K, Takahashi T, Ichinohe Y, Takeda Si, Tajima H, Kamae T, et al. Concept of a small satellite for sub-MeV and MeV all sky survey: The CAST mission. SPIE Proceedings; 2012. p. 84430E-E-12.
- A portable Si/CdTe Compton camera and its applications to the visualization of radioactive substances.Nucl Instrum Meth Phys Res Sect A. 2015; 787: 207-211
- In vivo simultaneous imaging with 99mTc and 18F using a Compton camera.Nucl Instrum Phys Med Biol. 2018; 63205006
- First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera.Sci Rep. 2017; 7: 2110
- Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI.Biochem Biophys Rep. 2016; 5: 211-215
- Compton camera using 3D position-sensitive scintillators coupled with large-area monolithic MPPC arrays.Nucl Instrum Meth Phys Res Sect A. 2013; 732: 403-407
- Demonstration of in-vivo multi-probe tracker based on a Si/CdTe semiconductor Compton Camera.IEEE Trans Nucl Sci. 2012; 59: 70-76
- Hitomi (ASTRO-H) X-ray astronomy satellite.SPIE. 2018; : 13
- Estimation of energy range measurements with newly developed Si/CdTe Compton camera for nuclear medicine imaging.IEEE Nucl Sci Symp Med Imaging Conf. 2010; : 1491-1493
- Compton camera study for high efficiency SPECT and benchmark with Anger system.Phys Med Biol. 2017; 62: 8794-8812
- Compton camera and prompt gamma ray timing: two methods for in vivo range assessment in proton therapy.Front Oncol. 2016; 6
- Compton cameras based on Si/CdTe double-sided strip detectors.Nucl Instrum Meth Phys Res Sect A. 2012; 695: 179-183
- Iterative image reconstruction using modified non-local means filtering for limited-angle computed tomography.Phys Med: Eur J Med Phys. 2016; 32: 1041-1051
- The effects of a finite number of projection angles and finite lateral sampling of projections on the propagation of statistical errors in transverse section reconstruction.Phys Med Biol. 1977; 22: 511
- Evaluation of SPECT angular sampling effects: continuous versus step-and-shoot acquisition.Soc Nucl Med. 1987; 28: 1308-1314
- The GEANT low energy Compton scattering (GLECS) package for use in simulating advanced Compton telescopes.New Astron Rev. 2004; 48: 221-225
- Applications and imaging techniques of a Si/CdTe Compton Gamma-Ray Camera.Phys Procedia. 2012; 37: 859-866
- Experimental performance of double-scattering Compton camera with anthropomorphic phantom.J Instrum. 2011; 6: C01024
- Comparison of continuous step-and-shoot versus step-and-shoot acquisition.Soc Nucl Med. 1996; 37: 2037-2040
- Considerations on system design, implementation and computer processing in SPECT.IEEE Trans Nucl Sci. 1982; 29: 1331-1342
- Streak artifact reduction in filtered backprojection using a level line-based interpolation method.J Nucl Med. 2000; 41: 1913-1919
- Analytic and iterative reconstruction algorithms in SPECT.J Nucl Med. 2002; 43: 1343-1358
Article info
Publication history
Accepted:
November 10,
2018
Received in revised form:
November 2,
2018
Received:
July 3,
2018
Identification
Copyright
© 2018 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.