Highlights
- •We present a CS-accelerated radial MS-CAIPIRINHA technique for first-pass myocardial MRI on integrated PET/MR systems.
- •The new technique allows MRI perfusion assessment with an extended anatomical coverage (six slices per RR interval).
- •Joint diagnosis with the simultaneously acquired three-dimensional PET benefits from an adequate coverage on the MRI-side.
Abstract
Purpose
Simultaneous acquisition of myocardial first-pass perfusion MRI and 18F-FDG PET viability
imaging on integrated whole-body PET/MR hybrid systems synergistically delivers both
functional and metabolic information on the tissue state. While PET viability scans
are inherently three-dimensional, conventional MR myocardial perfusion imaging is
typically performed using only three short-axis slices with a temporal resolution
of one RR-interval. To improve the integrated diagnostics, an acquisition and image
reconstruction method based on “Multi-Slice Controlled Aliasing In Parallel Imaging
Results IN Higher Acceleration (MS-CAIPIRINHA)” was developed extending anatomical
coverage for MR perfusion imaging to six short-axis slices per RR-interval.
Methods
An ECG-gated radial TurboFLASH MR pulse sequence with dual band excitation was implemented
on an integrated whole-body PET/MR system and a model-based reconstruction technique
was developed to fully reconstruct the undersampled CAIPIRINHA acquisitions. An 18F-FDG
viability PET scan was performed simultaneously to the MR protocol, additionally complemented
by a late enhancement MRI acquisition (LGE).
Results and conclusion
The developed imaging technique was tested in five patients with known collateralized
coronary total occlusions, resulting in improved characterization of perfusion across
areas of decreased tissue viability as indicated by the simultaneously determined
18F-FDG uptake. While conventional MR perfusion with only three slice positions was
occasionally missing substantial parts of the viable area, the new approach achieved
LV coverage only slightly inferior to LGE imaging and therefore better comparable
to PET results. The quality of first-pass enhancement curves was comparable between
conventional and radial MS-CAIPIRINHA-based acquisitions.
Keywords
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Article info
Publication history
Published online: July 16, 2019
Accepted:
June 17,
2019
Received in revised form:
June 5,
2019
Received:
March 29,
2019
Identification
Copyright
© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
