- •Effect of dose rate on biologically effective dose in hypofractionated regimens can be significant (i.e., >5%).
- •In the case of low dose rate, hypofractionation can lead to a significantly increased BED in the organ at risk.
- •Current study indicates that hypofractionated treatments should be delivered with the highest dose rate available.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Physica Medica: European Journal of Medical Physics
- A mathematical study to select fractionation regimen based on physical dose distribution and the linear-quadratic model.Int J Rad Oncol Biol Phys. 2012; 84: 829-833
- Utility of normal tissue-to-tumor a/b ratio when evaluating isodoses of isoeffective radiation therapy treatment plans.Int J Rad Oncol Biol Phys. 2013; 85: e81-e87
- The dependence of optimal fractionation schemes on the spatial dose distribution.Phys Med Biol. 2013; 58: 159-167
- Effect of radiation protraction in hypofractionated radiotherapy.Med Phys. 2018; 45: 3442-3448
- Normal tissue dose conformality measures to guide radiotherapy fractionation decisions.Med Phys. 2011; 38: 1799-1805
- Dose fractionation, dose rate and iso-effect relationships for normal tissue responses.Int J Rad Oncol Biol Phys. 1982; 8: 1981-1997
- 21 years of biologically effective dose.Br J Radiol. 2010; 83: 554-568
- An ‘Incomplete-repair’ model for survival after fractionated and continuous irradiations.Int J Rad Biol. 1985; 47: 319-339
- The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy.Br J Radiol. 1985; 58: 515-528
- Conditions for the equivalence of continuous and pulsed low dose rate brachytherapy.Int J Rad Oncol Biol Phys. 1991; 20: 181-190
- The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair.Int J Radiat Biol. 1997; 72: 351-374
- The mechanism of the induction by radiation of chromosome aberrations in tradescantia.J Genet. 1942; 44: 216-245
- Use of radiation protraction to escalate biologically effective dose to the treatment target.Med Phys. 2011; 38: 6553-6660
- Effect of variable dose rate on biologically effective dose.Int J Rad Biol. 2013; 89: 889-897
- Loss of biological effect in prolonged fraction delivery.Int J Rad Oncol Biol Phys. 2004; 59: 242-249
- Sublethal damage repair times for a late-responding tissue relevant to brachytherapy (and external-beam radiotherapy): implications for new brachytherapy protocols.Int J Rad Oncol Biol Phys. 1998; 41: 135-138
- Radiation Oncology Advances.Springer Science and Business Media, LLC, 2008
- Impact of spinal cord repair kinetics on the practice of altered fractionation schedules.Radiother Oncol. 1992; 25: 287-294
- Effect of radiation protraction in intensity-modulated radiation therapy with direct aperture optimization: a phantom study.Phys Med Biol. 2008; 53: 3279-3292
- Extending the linear–quadratic model for large fraction doses pertinent to stereotactic radiotherapy.Phys Med Biol. 2004; 49: 4825-4835
- The L-Q model is inappropriate to model high-dose per fraction effects.Semin Radiat Oncol. 2008; 18: 240-243
- The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction.Semin Radiat Oncol. 2008; 18: 234-239
- High-dose and fractionation effects in stereotactic radiation therapy: analysis of tumor control data from 2965 patients.Radiother Oncol. 2015; 115: 327-334
- Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia.Int J Radiat Oncol Biol Phys. 2011; 79: 1188-1195
- Compensation for changes in dose-rate in radical low-dose-rate brachytherapy: a radiobiological analysis of a randomised clinical trial.Radiother Oncol. 2004; 70: 63-74
- Is repair of DNA strand break damage from ionizing radiation second-order rather than first-order? A simpler explanation of apparently multiexponential repair.Radiat Res. 1999; 152: 124-136
- A new incomplete-repair model based on a 'reciprocal-time' pattern of sublethal damage repair.Acta Oncol. 1999; 38: 919-929