Highlights
- •The Dose Profiler is a charged fragment tracker designed for range monitoring in particle therapy.
- •The detector design, carefully optimized to operate in clinical environment, is described.
- •The characterization measurements have been performed using different experimental setup.
- •The obtained performances are suitable for range monitoring application.
Abstract
Particle therapy (PT) can exploit heavy ions (such as He, C or O) to enhance the treatment
efficacy, profiting from the increased Relative Biological Effectiveness and Oxygen
Enhancement Ratio of these projectiles with respect to proton beams. To maximise the
gain in tumor control probability a precise online monitoring of the dose release
is needed, avoiding unnecessary large safety margins surroundings the tumor volume
accounting for possible patient mispositioning or morphological changes with respect
to the initial CT scan. The Dose Profiler (DP) detector, presented in this manuscript,
is a scintillating fibres tracker of charged secondary particles (mainly protons)
that will be operating during the treatment, allowing for an online range monitoring. Such monitoring technique is particularly promising in the context
of heavy ions PT, in which the precision achievable by other techniques based on secondary
photons detection is limited by the environmental background during the beam delivery.
Developed and built at the SBAI department of “La Sapienza”, within the INSIDE collaboration
and as part of a Centro Fermi flagship project, the DP is a tracker detector specifically
designed and planned for clinical applications inside a PT treatment room. The DP
operation in clinical like conditions has been tested with the proton and carbon ions
beams of Trento proton-therapy center and of the CNAO facility. In this contribution
the detector performances are presented, in the context of the carbon ions monitoring
clinical trial that is about to start at the CNAO centre.
Keywords
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Article info
Publication history
Published online: August 19, 2019
Accepted:
July 14,
2019
Received in revised form:
June 24,
2019
Received:
February 6,
2019
Identification
Copyright
© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
