- •The Dose Profiler is a charged fragment tracker designed for range monitoring in particle therapy.
- •The detector design, carefully optimized to operate in clinical environment, is described.
- •The characterization measurements have been performed using different experimental setup.
- •The obtained performances are suitable for range monitoring application.
Particle therapy (PT) can exploit heavy ions (such as He, C or O) to enhance the treatment efficacy, profiting from the increased Relative Biological Effectiveness and Oxygen Enhancement Ratio of these projectiles with respect to proton beams. To maximise the gain in tumor control probability a precise online monitoring of the dose release is needed, avoiding unnecessary large safety margins surroundings the tumor volume accounting for possible patient mispositioning or morphological changes with respect to the initial CT scan. The Dose Profiler (DP) detector, presented in this manuscript, is a scintillating fibres tracker of charged secondary particles (mainly protons) that will be operating during the treatment, allowing for an online range monitoring. Such monitoring technique is particularly promising in the context of heavy ions PT, in which the precision achievable by other techniques based on secondary photons detection is limited by the environmental background during the beam delivery. Developed and built at the SBAI department of “La Sapienza”, within the INSIDE collaboration and as part of a Centro Fermi flagship project, the DP is a tracker detector specifically designed and planned for clinical applications inside a PT treatment room. The DP operation in clinical like conditions has been tested with the proton and carbon ions beams of Trento proton-therapy center and of the CNAO facility. In this contribution the detector performances are presented, in the context of the carbon ions monitoring clinical trial that is about to start at the CNAO centre.
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- Charged-particle therapy in cancer: clinical uses and future perspectives.Nature Rev Clinical Oncol. 2017; 14: 483-495https://doi.org/10.1038/nrclinonc.2017.30
- Relative biological effectiveness (RBE) values for proton beam therapy. variations as a function of biological endpoint, dose, and linear energy transfer.Phys Med Biol. 2014; 59: R419-R472https://doi.org/10.1088/0031-9155/59/22/r419
- New ions for therapy.Int J Particle Therapy. 2015; 2: 428-438https://doi.org/10.14338/IJPT-15-00027.1
- Range uncertainties in proton therapy and the role of monte carlo simulations.Phys Med Biol. 2012; 57: R99-R117https://doi.org/10.1088/0031-9155/57/11/r99
- Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (protocol 1001).Cancer Med. 2018; 7: 351-359https://doi.org/10.1002/cam4.1305
- Probabilistic dose distribution from interfractional motion in carbon ion radiation therapy for prostate cancer shows rectum sparing with moderate target coverage degradation.PLOS ONE. 2018; 13: 1-19https://doi.org/10.1371/journal.pone.0203289
- Prompt gamma imaging for inávivo range verification of pencil beam scanning proton therapy.Int J Radiation Oncol Biol Phys. 2017; 99: 210-218https://doi.org/10.1016/j.ijrobp.2017.04.027
- A full-scale clinical prototype for proton range verification using prompt gamma-ray spectroscopy.Phys Med Biol. 2018; 63185019https://doi.org/10.1088/1361-6560/aad513
- On- and off-line monitoring of ion beam treatment.Nucl Instrum Methods Phys Res Section A. 2016; 809 (advances in detectors and applications for medicine): 113-119https://doi.org/10.1016/j.nima.2015.06.056
- Online proton therapy monitoring: clinical test of a silicon-photodetector-based in-beam pet.Sci Rep. 2018; 8: 4100https://doi.org/10.1038/s41598-018-22325-6
- Monte carlo simulation tool for online treatment monitoring in hadrontherapy with in-beam pet: A patient study.Physica Medica. 2018; 51: 71-80https://doi.org/10.1016/j.ejmp.2018.05.002
- Monitoring of hadrontherapy treatments by means of charged particle detection.Frontiers in Oncology. 2016; 6: 177https://doi.org/10.3389/fonc.2016.00177
- Experimental study of nuclear fragmentation of 200 and 400 MeV/u12c ions in water for applications in particle therapy.Phys Med Biol. 2013; 58: 8265-8279https://doi.org/10.1088/0031-9155/58/23/8265
- Secondary beam fragments produced by 200 MeVu-112c ions in water and their dose contributions in carbon ion radiotherapy.New J Phys. 2008; 10075003https://doi.org/10.1088/1367-2630/10/7/075003
- Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u12cbeam.Phys Med Biol. 2014; 59: 1857-1872https://doi.org/10.1088/0031-9155/59/7/1857
- Secondary radiation measurements for particle therapy applications: charged particles produced by 4he and 12c ion beams in a PMMA target at large angle.Phys Med Biol. 2018; 63055018https://doi.org/10.1088/1361-6560/aaa36a
- Wheadon, Inside in-beam positron emission tomography system for particle range monitoring in hadrontherapy.J Med Imaging. 2016; 4: 1-12https://doi.org/10.1117/1.JMI.4.1.011005
- Design of a new tracking device for on-line beam range monitor in carbon therapy.Physica Medica. 2017; 34: 18-27https://doi.org/10.1016/j.ejmp.2017.01.004
- products, scintillating optical fibers.Brochure. 2010; (URL: https://www.crystals.saint-gobain.com/sites/imdf.crystals.com/files/documents/fiber-brochure.pdf)
- Basic32adc a front-end asic for sipm detectors.in: 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC). 2013: 1-6https://doi.org/10.1109/NSSMIC.2013.6829781
- The cnao dose delivery system for modulated scanning ion beam radiotherapy.Medical Physics. 2015; 42: 263-275https://doi.org/10.1118/1.4903276
Ferrari A, Sala PR, Fasso A, Ranft J, FLUKA: a multi-particle transport code (Program version 2005), CERN-2005-010, SLAC-R-773, INFN-TC-05-11.
- The fluka code: an accurate simulation tool for particle therapy.Front Oncol. 2016; 6: 116https://doi.org/10.3389/fonc.2016.00116
- Proton beam characterization in the experimental room of the trento proton therapy facility.Nucl Instrum Methods Phys Res Section A. 2017; 869: 15-20https://doi.org/10.1016/j.nima.2017.06.017
- Use of the hough transformation to detect lines and curves in pictures.Commun ACM. 1972; 15: 11-15https://doi.org/10.1145/361237.361242
Published online: August 19, 2019
Accepted: July 14, 2019
Received in revised form: June 24, 2019
Received: February 6, 2019
© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.