Highlights
- •Predictions of the mean heart dose were made using a deep neural network.
- •Errors in prediction were small compared to other methods utilised in the literature.
- •Only parameters available at treatment planning were used for each prediction.
- •The optimal neural network was comprised of a single hidden layer of 30 neurons.
- •94% of all prediction errors were below 0.2 Gy and 100% were below 0.5 Gy.
Abstract
Purpose
We investigated if a neural network could be used to predict the change in mean heart
dose when a patient's heart deviates from its planned position during radiotherapy
treatment.
Methods
Predictions were made based on parameters available at the time of treatment planning.
The dose prescription, deep inspiration breath-hold (DIBH) amplitude, heart volume,
lung volume, V90% and mean heart dose were used to predict the increase in dose to
the heart when a shift towards the treatment field was undertaken. The network was
trained using 3 mm, 5 mm and 7 mm shifts in heart positions for 50 patients' giving
150 data points in total. The neural network architecture was also varied to find
the most optimal network design. The final neural network was then tested using cross-validation
to evaluate the model's ability to generalise to new data.
Results
The optimal neural network found was comprised of a single hidden layer of 30 neurons.
Based on twenty train/test splits, 94% of all prediction errors were below 0.2 Gy,
97.3% were below 0.3 Gy and 100% were below 0.5 Gy. The average RMSE and maximum prediction
error over all train/test splits were 0.13 Gy and 0.5 Gy respectively.
Conclusions
Our approach using a neural network provides a clinically acceptable estimate of the
increase in Mean Heart Dose (MHD), without the need for further imaging, contouring
or evaluation. The trained neural network gives clinicians the information and tools
required to evaluate what shift in heart position would be acceptable and which scenarios
require immediate action before treatment continues.
Keywords
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Article info
Publication history
Published online: August 26, 2019
Accepted:
August 15,
2019
Received in revised form:
August 10,
2019
Received:
December 22,
2018
Identification
Copyright
© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.