- •Theoretical calculation of the risk for second primary cancer after breast radiotherapy.
- •Comparison between proton and photon therapy and two risk models.
- •CTs in three different states.
- •Proton therapy gives lower risks in all scenarios.
Materials and methods
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Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer Incidence and Mortality Worldwide: IARC CancerBase. IARC CancerBase. 2013;11.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) EBCTCG, Darby S, McGale P, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet (London, England). 2011;378:1707–16.
- Risk of second cancer following radiotherapy.Phys Medica. 2017; 42: 211-212
- Second primary cancers after adjuvant radiotherapy in early breast cancer patients: a national population based study under the Danish Breast Cancer Cooperative Group (DBCG).Radiother Oncol. 2013; 106: 42-49
Dasu A, Toma-Dasu I. Long-term effects and secondary tumors. Compr Biomed Phys. Amsterdam: Elsevier; 2014. p. 223–233.
- Second primary tumors after radiotherapy for malignancies.Strahlentherapie und Onkol. 2002; 178: 357-362
- Carcinogenic effects of scattered dose associated with radiation therapy.Int J Radiat Oncol Biol Phys. 1989; 17: 623-629
- Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy.Acta Oncol. 2016; 55: 577-583
- Model-based approach for quantitative estimates of skin, heart, and lung toxicity risk for left-side photon and proton irradiation after breast-conserving surgery.Acta Oncol. 2017; 56: 730-736
- Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer.Acta Oncol. 2015; 54: 1032-1039
- Impact of physiological breathing motion for breast cancer radiotherapy with proton beam scanning – an in silico study.Phys Medica. 2017; 39: 88-94
- The influence of breathing motion and a variable relative biological effectiveness in proton therapy of left-sided breast cancer.Acta Oncol. 2017; 56: 1428-1436
- A model for the relative biological effectiveness of protons: the tissue specific parameter α/β of photons is a predictor for the sensitivity to LET changes.Acta Oncol. 2013; 52: 580-588
- Inclusion of a variable RBE into proton and photon plan comparison for various fractionation schedules in prostate radiation therapy.Med Phys. 2017; 44: 810-822
- Disregarding RBE variation in treatment plan comparison may lead to bias in favor of proton plans.Med Phys. 2014; 41
Dasu A, Toma-Dasu I. Models for the risk of secondary cancers from radiation therapy. Phys Medica 2017;42.
- The use of risk estimation models for the induction of secondary cancers following radiotherapy.Acta Oncol. 2005; 44: 339-347
- Radiation-induced secondary cancers from IMRT and CRT for head-and-neck tumours : differences in risk estimation and influence of risk models.([MSc thesis]) Stockholm University, 2011
ICRP. ICRP Publication 103. The 2007 Recommendations of the International Commission on Radiological Protection. Annals of the ICRP 37 [2-4], 1-332, 2007.
- Dose – effect models for risk – relationship to cell survival parameters.Acta Oncol. 2005; : 829-835
Davis RH. Production and killing of second cancer precursor cells in radiation therapy: in regard to Hall and Wuu (Int J Radiat Oncol Biol Phys 2003;56:83-88). Int J Radiat Oncol Biol Phys.
- Radiation risk estimates after radiotherapy: application of the organ equivalent dose concept to plateau dose-response relationships.Radiat Environ Biophys. 2005; 44: 235-239
- The impact of neutrons in clinical proton therapy.Front Oncol. 2015; : 5
- Risk of second primary cancer after breast cancer treatment.Eur J Cancer Care. 2014; 23: 51-64
- Second cancer risk after 3D-CRT, IMRT and VMAT for breast cancer.Radiother Oncol. 2014; 110: 471-476
- Long-term risks of secondary cancer for various whole and partial breast irradiation techniques.Radiother Oncol. 2018; 128: 428-433
- The potential role of intensity-modulated proton therapy in the regional nodal irradiation of breast cancer: a treatment planning study.Clin Oncol. 2020; 32: 26-34
- Postoperative proton radiotherapy for localized and locoregional breast cancer: potential for clinically relevant improvements?.Int J Radiat Oncol Biol Phys. 2010; 76: 685-697
- A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data.Phys Med Biol. 2015; 60: 8399-8416
- The incorporation of the concept of minimum RBE (RBEmin) into the linear-quadratic model and the potential for improved radiobiological analysis of high-LET treatments.Int J Radiat Biol. 2007; 83: 27-39
- Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios.Radiat Oncol. 2016; 11
- RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility.Int J Radiat Biol. 1998; 74: 501-509
- Measurements of the neutron dose equivalent for various radiation qualities, treatment machines and delivery techniques in radiation therapy.Phys Med Biol. 2014; 59: 2457-2468