Highlights
- •A new class of multi-parameter quantitative MRI protocols is presented.
- •The derived brain maps show high signal-to-noise ratio and accuracy.
- •The RESUMEN schemes can be easily integrated in research and routine protocols.
Abstract
Purpose
To introduce a class of fast 3D quantitative MRI (qMRI) schemes (RESUMEN, for ) that allow for a thorough characterization of microstructural properties of brain
tissues.
Methods
An arbitrary multi-echo GRE acquisition optimized for quantitative susceptibility
mapping (QSM) is complemented with an appropriate low flip-angle GRE sequence drawn
from four possible choices. The acquired signals are processed to analytically derive
the longitudinal relaxation () and free induction decay () rates, as well as the proton density (PD) and QSM. A comprehensive modeling of the
excitation and profiles and of the RF-spoiling is included in the acquisition and processing pipeline.
Results
The RESUMEN maps appear homogeneous throughout the field-of-view and exhibit comparable values
and high SNR across the considered range of N values.
Conclusions
The introduced schemes represent a class of robust and flexible strategies to derive
a thorough and fast qMRI study, suitable for a whole-brain acquisition with isotropic
voxel resolution of 700 m in less than 15 min.
Keywords
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Article info
Publication history
Published online: June 22, 2021
Accepted:
April 2,
2021
Received in revised form:
March 16,
2021
Received:
January 29,
2021
Identification
Copyright
© 2021 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
