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The feasibility of an approximate irregular field dose distribution simulation program applied to a respiratory motion compensation system

  • Lai-Lei Ting
    Affiliations
    Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan
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  • Ai-Ho Liao
    Affiliations
    Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan

    Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan
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  • Muthusankar Ganesan
    Affiliations
    Department of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan

    Department of Industrial Chemistry, Alagappa University, Karaikudi 630001, Tamil Nadu, India
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  • Chia-Chun Kuo
    Affiliations
    Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

    School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan
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  • Hsiao-Wei Yu
    Affiliations
    Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan
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  • Po-Jung Chen
    Affiliations
    Department of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan
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  • Shiu-Chen Jeng
    Affiliations
    Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
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  • Jeng-Fong Chiou
    Affiliations
    Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan
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  • Ho-Chiao Chuang
    Correspondence
    Corresponding author.
    Affiliations
    Department of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan
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      Highlights

      • Dose distribution was simulated by the developed approximate irregular field dose distribution program.
      • The program combined with a compensation bed to simulate the clinical application of radiotherapy.
      • The present findings indicate that it is possible to reach a gamma passing rate exceeded 70% under respiratory motion.

      Abstract

      Purpose

      This study optimized our previously proposed simulation program for the approximate irregular field dose distribution (SPAD) and applied it to a respiratory motion compensation system (RMCS) and respiratory motion simulation system (RMSS). The main purpose was to rapidly analyze the two-dimensional dose distribution and evaluate the compensation effect of the RMCS during radiotherapy.

      Methods

      This study modified the SPAD to improve the rapid analysis of the dose distribution. In the experimental setup, four different respiratory signal patterns were input to the RMSS for actuation, and an ultrasound image tracking algorithm was used to capture the real-time respiratory displacement, which was input to the RMCS for actuation. A linear accelerator simultaneously irradiated the EBT3 film. The gamma passing rate was used to verify the dose similarity between the EBT3 film and the SPAD, and conformity index (CI) and compensation rate (CR) were used to quantify the compensation effect.

      Results

      The Gamma passing rates were 70.48–81.39% (2%/2mm) and 88.23–96.23% (5%/3mm) for various collimator opening patterns. However, the passing rates of the SPAD and EBT3 film ranged from 61.85% to 99.85% at each treatment time point. Under the four different respiratory signal patterns, CR ranged between 21% and 75%. After compensation, the CI for 85%, 90%, and 95% isodose constraints were 0.78, 0.57, and 0.12, respectively.

      Conclusions

      This study has demonstrated that the dose change during each stage of the treatment process can be analyzed rapidly using the improved SPAD. After compensation, applying the RMCS can reduce the treatment errors caused by respiratory movements.

      Keywords

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