Highlights
- •Prompt-gamma emission in proton therapy is investigated.
- •Results of experiments on phantoms are shown along with Geant4 simulations.
- •Several Geant4 versions and physics lists are tested.
- •None of the configurations is able to fully reproduce the experimental data.
- •It is not the most recent Geant4 version which gives the best agreement with data.
Abstract
Purpose
Methods
Results
Conclusions
Keywords
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Subscribe to Physica Medica: European Journal of Medical PhysicsReferences
Wrońska A, Dauvergne D. In: Radiation detection systems, vol. 2. Ed. by Iniewski K, Iwańczyk J. preprint at https://hal.archives-ouvertes.fr/hal-03085504/document.CRCPress/Routledge; 2021. Chap. 6.
NuPECC report 2014: Nuclear Physics for Medicine. http://www.nupecc.org/pub/npmed2014.pdf. Accessed: 2021-07-13.
- A deep learning approach for converting prompt gamma images to proton dose distributions: A Monte Carlo simulation study.Phys Med. 2020; 69: 110-119https://doi.org/10.1016/j.ejmp.2019.12.006
- First clinical application of a prompt gamma based in vivo proton range verification system.Radiother Oncol. 2016; 118: 232-237https://doi.org/10.1016/j.radonc.2016.01.004
- A full-scale clinical prototype for proton range verification using prompt gamma-ray spectroscopy.Phys Med Biol. 2018; 63185019https://doi.org/10.1088/1361-6560/aad513
- Online proton therapy monitoring: clinical test of a Silicon-photodetector-based in-beam PET.Sci Rep. 2018; 8: 4100https://doi.org/10.1038/s41598-018-22325-6
- 3D prompt gamma imaging for proton beam range verification.Phys Med Biol. 2018; 63035019https://doi.org/10.1088/1361-6560/aaa203
- Development of a Compton camera for medical applications based on silicon strip and scintillation detectors.Nucl Instrum Methods Phys Res A. 2015; 787: 98-101https://doi.org/10.1016/j.nima.2014.11.042
- Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams.Phys Med Biol. 2016; 61: 5149-5165https://doi.org/10.1088/0031-9155/61/14/5149
- Progress towards a semiconductor Compton camera for prompt gamma imaging during proton beam therapy for range and dose verification.J Instrum. 2018; 13: C01036https://doi.org/10.1088/1748-0221/13/01/C01036
- Simulation of proton range monitoring in an anthropomorphic phantom using multi-slat collimators and time-of-flight detection of prompt-gamma quanta.Phys Med. 2018; 54: 1-14https://doi.org/10.1016/J.EJMP.2018.09.001
- Characterization of components of a scintillation-fiber-based Compton Camera.Acta Phys Pol B. 2020; 51: 17-25https://doi.org/10.5506/APhysPolB.51.17
- Characterization of prompt gamma ray emission for in vivo range verification in particle therapy: A simulation study.Phys Med. 2019; 62: 20-32https://doi.org/10.1016/J.EJMP.2019.04.023
- Simulation of prompt gamma-ray emission during proton radiotherapy.Phys Med Biol. 2012; 17: 5459-5472https://doi.org/10.1088/0031-9155/57/17/5459
Werner CJ (editor). MCNP Users Manual - Code Version 6.2. LA-UR-17-29981: https://laws.lanl.gov/vhosts/mcnp.lanl.gov/pdf_files/la-ur-17-29981.pdf. Accessed: 2021-07-13. 2017.
The TALYS package. https://tendl.web.psi.ch/tendl_2019/talys.html. Accessed: 2021-07-13.
- EMPIRE: Nuclear reaction model code system for data evaluation.Nucl Data Sheets. 2007; 108: 2655https://doi.org/10.1016/j.nds.2007.11.003
- The FLUKA code: An accurate simulation tool for particle therapy.Front Oncol. MAY 2016; 6: 11https://doi.org/10.3389/fonc.2016.00116
- Recent developments in GEANT4.Nucl Instrum Methods Phys Res A. 2016; 835: 186-225https://doi.org/10.1016/j.nima.2016.06.125
- Advances in Geant4 applications in medicine.Phys Med. 2020; 70: 224-227https://doi.org/10.1016/J.EJMP.2020.01.019
- Range assessment in particle therapy based on prompt -ray timing measurements.Phys Med Biol. 2014; 59: 5399-5422https://doi.org/10.1088/0031-9155/59/18/5399
- Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification.Radiother Oncol. 2017; 125: 534-540https://doi.org/10.1016/j.radonc.2017.10.013
- Capability of MLEM and OE to detect range shifts with a compton camera in particle therapy.IEEE Trans Radiat Plasma Med Sci. 2020; 4: 233-242https://doi.org/10.1109/TRPMS.2019.2937675
- Assessment and improvements of Geant4 hadronic models in the context of prompt-gamma hadrontherapy monitoring.Phys Med Biol. 2014; 59: 1747-1772https://doi.org/10.1088/0031-9155/59/7/1747
- Assessment of Geant4 prompt-gamma emission yields in the context of proton therapy monitoring.Front Oncol. 2016; 6: 10https://doi.org/10.3389/fonc.2016.00010
Vanstalle M, Mattei I, Sarti A, et al. Benchmarking Geant4 hadronic models for prompt- monitoring in carbon ion therapy. Med Phys 2017;8(44):4276–86. doi: 10.1002/mp.12348.
Physics Reference Manual, Release 10.7. https://geant4-userdoc.web.cern.ch/UsersGuides/PhysicsReferenceManual/fo/PhysicsReferenceManual.pdf. Accessed: 2021-07-13.
- Spectroscopic study of promptgamma emission for range verification in proton therapy.PhysMed. 2017; 34: 7-17https://doi.org/10.1016/j.ejmp.2017.01.003
- Phase Space Generation for Proton and Carbon Ion Beams for External Users’ Applications at the Heidelberg Ion Therapy Center.Front Oncol. 2016; 5: 297https://doi.org/10.3389/fonc.2015.00297
Eickhoff H, Dr. Weinrich U, and Alonso J. Design Criteria for Medical Accelerators. In: Ion beam therapy: Fundamentals, technology, clinical applications. Ed. by Linz U. Springer, 2012:325–43.
- Simulation and experimental verification of prompt gamma-ray emissions during proton irradiation.Phys Med Biol. 2015; 60: 4197-4207https://doi.org/10.1088/0031-9155/60/10/4197
Guide For Physics Lists, Release 10.7. https://geant4-userdoc.web.cern.ch/UsersGuides/PhysicsListGuide/fo/PhysicsListGuide.pdf. Accessed: 2021-07-13.
- Physics settings for using the Geant4 toolkit in proton therapy.IEEE Trans Nucl Sci. 2008; 55: 1018-1025https://doi.org/10.1109/TNS.2008.922816
Cirrone G. Hadrontherapy example. https://twiki.cern.ch/twiki/bin/view/Geant4/AdvancedExamplesHadrontherapy. Accessed: 2021-07-13.
Guide For Physics Lists, Release 10.4. https://geant4-userdoc.web.cern.ch/UsersGuides/PhysicsListGuide/BackupVersions/V10.4/fo/PhysicsListGuide.pdf. Accessed: 2021-07-13.
Guide For Physics Lists, Release 10.5. https://geant4-userdoc.web.cern.ch/UsersGuides/PhysicsListGuide/BackupVersions/V10.5-2.0/fo/PhysicsListGuide.pdf. Accessed: 2021-07-13.
Guide for physics lists, Release 10.6. https://geant4-userdoc.web.cern.ch/UsersGuides/PhysicsListGuide/BackupVersions/V10.6c/fo/PhysicsListGuide.pdf. Accessed: 2021-07-13.
Rose PF. ENDF-201: ENDF/B-VI summary documentation. 1991. doi:10.2172/10132931. url: https://www.osti.gov/biblio/10132931.
Koning A, Rochman D, Sublet JC, Dzysiuk N, Fleming M, and van der Marck S. TENDL: Complete nuclear data library for innovative nuclear science and technology. Nucl Data Sheets 2019;155. Special Issue on Nuclear Reaction Data:1–55. doi: 10.1016/j.nds.2019.01.002.
- Shape of the spectral line and gamma angular distribution of the 12C(p, p’4.44)12C reaction.Acta Phys Pol B. 2018; 49: 1637-1652https://doi.org/10.5506/APhysPolB.49.1637
NDS IAEA Interactive chart of nuclides. https://www-nds.iaea.org/relnsd/vcharthtml/VChartHTML.html. Accessed: 2021-07-13.