Highlights
- •A methodology for radiopharmaceutical imaging based on 3D-CZT camera is proposed.
- •The event selection method and image reconstruction algorithm are optimized.
- •Performance of radiopharmaceutical imaging with 3D-CZT are preliminarily studied.
Abstract
Purpose
The study proposes the use of three-dimensional CdZnTe Compton camera (3D-CZT CC)
for radiopharmaceutical imaging and investigates the influence factors using a 3D-printed
mouse phantom.
Methods
The event selection method and image reconstruction algorithm are optimized by Monte
Carlo simulations and mouse phantom experiments.
Results
Simulation results show that the intrinsic energy resolution and spatial resolution
of 3D-CZT cause a certain deviation in the calculated Compton scattering angle and
Compton axis. Such deviation causes the imaging quality to deteriorate. By selecting
events whose distance between Compton and photoelectronic interactions are larger
than 10 mm, the mean deviation of the Compton axis could be reduced to less than 10%.
Using the ordered origin ensemble algorithm with resolution recovery, the artifacts
around organs where the radiopharmaceutical was placed are reduced, and the quality
of the reconstruction results are improved compared to the results with simple back
projection and origin ensembles algorithms. The phantom study shows that the 3D-CZT
CC imaging device could visualize the radiopharmaceuticals distribution by 15 min
detection.
Conclusions
Through the analysis of this study, the feasibility of 3D-CZT CC for in-vivo distribution measurement of radiopharmaceuticals is demonstrated, and the quality
of reconstruction result has been improved.
Keywords
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Article info
Publication history
Published online: March 11, 2022
Accepted:
March 4,
2022
Received in revised form:
March 3,
2022
Received:
September 15,
2021
Identification
Copyright
© 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.
