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Research Article| Volume 107, 102552, March 2023

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18F-alfatide II internal dosimetry using the ICRP 110 adult reference phantoms and the ICRP 103 tissue weighting factors

Published:February 27, 2023DOI:https://doi.org/10.1016/j.ejmp.2023.102552

      Highlights

      • Internal dosimetry for Alfatide II using the ICRP 110 phantoms for the first time.
      • The effective dose of Alfatide II using the ICRP 103 method is 1.33E-02 mSv/MBq.
      • The estimated effective dose in this study is lower than previously published data.
      • The lungs have the highest contribution to the effective dose.
      • The effective dose coefficient of Alfatide II is lower than FDG.

      Abstract

      Purpose

      18F-alfatide II is an arginine-glycine-aspartate (RGD) peptide-based PET tracer with promising imaging properties and pharmacokinetics. This study aims to calculate the absorbed and effective doses of 18F-alfatide II using the ICRP 110 adult reference phantoms and the ICRP 103 tissue weighting factors.

      Methods

      The MIRD method was used in this study to calculate the absorbed dose of organs and tissues. The biokinetic data were taken from a previous study. These data are based on the whole-body PET imaging of mice.

      Results

      The results show that the effective dose per unit activity administered of 18F-alfatide II is 1.33E-02 mSv/MBq. The urinary bladder wall receives the highest absorbed dose due to the administration of this radiopharmaceutical. Also, the effective dose of 18F-alfatide II is lower than that of 18F-FDG and some other RGD peptide-based tracers.

      Conclusions

      Dose calculation using ICRP 110 voxelized adult reference phantoms and ICRP 103 tissue weighting factors leads to more realistic and accurate results for 18F-alfatide II compared to the stylized phantoms. The calculated effective dose of 18F-alfatide II in the present study is lower than that of previously published data.

      Keywords

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