Highlights
- •Relevance of Internal Bremsstrahlung (IB) in 32P DPK evaluation was highlighted.
- •DPK including IB is up to 40% larger than the values available in literature.
- •IB inclusion in MC codes among processes related to beta decay is advisable.
Abstract
Purpose
In nuclear medicine, Dose Point Kernels (DPKs), representing the energy deposited
all around a point isotropic source, are extensively used for dosimetry and are usually
obtained by Monte Carlo (MC) simulations. For beta-decaying nuclides, DPK is usually
estimated neglecting Internal Bremsstrahlung (IB) emission, a process always accompanying
the beta decay and consisting in the emission of photons having a continuous spectral
distribution. This work aims to study the significance of IB emission for DPK estimation
in the case of 32P and provide DPK values corrected for the IB photon contribution.
Methods
DPK, in terms of the scaled absorbed dose fraction, , was first estimated by GAMOS MC simulation using the standard beta decay spectrum
of 32P, . Subsequently, an additional source term accounting for IB photons and their spectral
distribution was defined and used for a further MC simulation, thus evaluating the
contribution of IB emission to DPK values, . The relative percent difference, δ, between the DPKs obtained by the two approaches,
vs. , was studied as a function of the radial distance, R.
Results
As far as the energy deposition is mainly due to the beta particles, IB photons does
not significantly contribute to DPK; conversely, for larger R, values are higher by 30–40% than .
Conclusions
The inclusion of IB emission in the MC simulations for DPK estimations is recommended,
as well as the use of the DPK values corrected for IB photons, here provided.
Keywords
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References
- Fundamentals of internal radiation dosimetry.in: Signore Alberto Nuclear medicine and molecular imaging. Elsevier, 2022: 607-621https://doi.org/10.1016/B978-0-12-822960-6.00142-3
- A monte carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures.Phys Med. 2018; 49: 52-57https://doi.org/10.1016/j.ejmp.2018.05.005
- Internal dosimetry for TARE therapies by means of GAMOS Monte Carlo simulations.Phys Med. 2019; 64: 245-251https://doi.org/10.1016/j.ejmp.2019.07.024
- Monte Carlo 90Y PET/CT dosimetry of unexpected focal radiation-induced lung damage after hepatic radioembolisation.Phys Med Biol. 2020; 65: 235014https://doi.org/10.1088/1361-6560/abbc80
- Relevance of artefacts in 99mTc-MAA SPECT scans on pre-therapy patient-specific 90Y TARE internal dosimetry: a GATE Monte Carlo study.Phys Med Biol. 2022; 67: 115002https://doi.org/10.1088/1361-6560/ac6b0f
- GATE Monte Carlo dosimetry in 90Y TARE planning: influence of simulation parameters and image resampling on dosimetric accuracy and optimization of computational times.AAPP Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Fisiche, Matematiche e Naturali. 2021; 99: 1-35https://doi.org/10.1478/AAPP.992A4
- Monte Carlo methods in nuclear medicine.in: Signore Alberto Nuclear Medicine and Molecular Imaging. Elsevier, 2022: 587-606 (ISBN 9780128229804, https://doi.org/10.1016/B978-0-12-822960-6.00136-8)
- MIRD Pamphlet no 7 – Distribution of absorbed dose around point sources of electrons and beta particles in water and other media.J Nucl Med. 1971; 12: 5-23
- Discrete radioisotope processes.in: Hine G.J. Brownell G.L. Radiation Dosimetry. Academic, New York1956
- Electron-photon Monte Carlo calculations: The ETRAN code.Appl Radiat Isot. 1991; 42: 917-941
- Accurate determination of dose-point-kernel functions close to the origin using Monte Carlo simulations.Med Phys. 2004; 31: 814-818https://doi.org/10.1118/1.1668393
- Calculation of electron and isotopes dose point kernels with FLUKA Monte Carlo code for dosimetry in nuclear medicine therapy.Med Phys. 2011; 38: 3944-3954https://doi.org/10.1118/1.3586038
- A dose point kernel database using GATE Monte Carlo simulation toolkit for nuclear medicine applications: comparison with other Monte Carlo codes.Med Phys. 2012; 39: 5238-5247https://doi.org/10.1118/1.4737096
- Evaluating the application of tissue-specific dose kernels instead of water dose kernels in internal dosimetry: A Monte Carlo study.Cancer Biother Radiopharm. 2016; 31: 367-379
- Dose point kernels for 2,174 radionuclides.Med Phys. 2019; 46: 5284-5293https://doi.org/10.1002/mp.13789
- Calculation of dose point kernel values for monoenergetic electrons and beta emitting radionuclides: Intercomparison of Monte Carlo codes.Rad Phys Chem. 2021; 181: 109327
- Enhancement of radiation exposure risk from β-emitter radionuclides due to Internal Bremsstrahlung effect: A Monte Carlo study of 90Y case.Phys Med. 2020; 76: 159-165https://doi.org/10.1016/j.ejmp.2020.06.018
- Experimental evidence of Internal Bremsstrahlung photons from 90Y decay.Phys Med. 2021; 90: 158-163https://doi.org/10.1016/j.ejmp.2021.10.006
- Internal Bremsstrahlung emission during 32P decay.Rad Meas. 2022; 155: 106799
- Novel application of 32P brachytherapy: treatment of angiolymphoid hyperplasia with eosinophilia in the right auricle with 8-year follow-up.Cancer Biother Radiopharm. 2018; 33: 282-284https://doi.org/10.1089/cbr.2018.2468
- Novel EUS-guided brachytherapy treatment of pancreatic cancer with phosphorus-32 microparticles: first United States experience.VideoGIE. 2019; 4: 223-225
- A preliminary safety assessment of vertebral augmentation with 32P brachytherapy bone cement.Phys Med Biol. 2022; 67: 075007
- Protocol for the measurement of the absorbed dose rate to water for a planar 32P beta emitting brachytherapy source: A multi-institutional validation.Brachytherapy. 2022; 21: 120-127
- GAMOS: A GEANT4-based easy and flexible framework for nuclear medicine applications.in: 2008 IEEE Nucl Sci Symp Conf Rec. 2008: 3162-3168https://doi.org/10.1109/NSSMIC.2008.4775023
- Gamos: A framework to do Geant4 simulations in different physics fields with an user-friendly interface.Nucl Instrum Methods Phys Res A. 2014; 735: 304-313
- Geant4 - A simulation toolkit.Nucl Instrum Methods Phys Res A. 2003; 506: 250-303
- Geant4 developments and applications.IEEE Trans Nucl Sci. 2006; 53: 270-278
- 2016 Recent Developments in Geant4.Nucl Instrum Methods Phys Res A. 2016; 835: 186-225
NDS_IAEA 2022. IAEA Nuclear Data Service (NDS). https://www-nds.iaea.org/relnsd/vcharthtml/VChartHTML.html. Accessed October 8, 2022.
- Radioactive decays in Geant4.IEEE Trans Nucl Sci. 2013; 60: 2966-2983
- Validation of Geant4-based radioactive decay simulation.IEEE Trans Nucl Sci. 2013; 60: 2984-2997
Geant4 Collaboration 2022. GEANT4 Physics Reference Manual, Version 10.3. https://GEANT4.web.cern.ch/. Accessed October 8, 2022.
- Nucl Data Sheets. 2011; 112: 2199-2355https://doi.org/10.1016/j.nds.2011.08.004
- On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies.Philos Trans R Soc Lond. 1825; 115: 513-585https://doi.org/10.1098/rstl.1825.0026
- The origin and reduction of spurious extrahepatic counts observed in 90Y non-TOF PET imaging post radioembolization.Phys Med Biol. 2018; 63 (075016–75031)https://doi.org/10.1088/1361-6560/aab4e9
- A method for the solution of certain problems in least squares.Q Appl Math. 1944; 2: 164-168
- An algorithm for least-squares estimation of nonlinear parameters.SIAM J Appl Math. 1963; 11: 431-441
- Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planning.Int J Radiat Oncol Biol Phys. 2006; 65: 1249-1259
- Improved point kernels for electron and beta-ray dosimetry.in: Progress Report NBSIR. U.S. Atomic Energy Commision, Washington, D.C.1973: 73-107 (20545)
- Dose point-kernels for radionuclide dosimetry.in: Zaidi H. Sgouros G. Series in Medical Physics and Biomedical Engineering Therapeutic applications of Monte Carlo calculations in nuclear medicine. Institute of Physics Publishing, Bristol and Philadelphia2003: 364 .
- Calculation of photon energy deposition kernels and electron dose point kernels in water.Med Phys. 2005; 32: 685-699https://doi.org/10.1118/1.1861412
- Internal and external bremsstrahlung accompanying the beta rays of 32P.Phys Rev. 1955; 97: 419-427https://doi.org/10.1103/PhysRev.97.419
Article info
Publication history
Published online: April 27, 2023
Accepted:
April 7,
2023
Received in revised form:
March 3,
2023
Received:
December 2,
2022
Identification
Copyright
© 2023 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica e Sanitaria.