The present focus issue of Physica Medica contains contributions presented in relation to the previous scientific congress of the French Society of Medical Physics (SFPM) that was organized in Rennes in the spring 2021. The SFPM congress, which occurs annually during 3 days, aims at bringing together physicists, dosimetrists, and other professionals involved in cancer therapy or in medical imaging to discuss current topics related to the three main fields of activity of the medical physicist i.e.